Search for dissertations about: "Protein function"

Showing result 1 - 5 of 2695 swedish dissertations containing the words Protein function.

2. 1. Protein complexes : assembly, structure and function

   Author : Kristina Wilhelm; Ludmilla Ludmilla Morozova-Roche; Catharina Svanborg; Umeå universitet; []
   Keywords : HAMLET; ELOA; lysozyme; amyloid; medicinsk biokemi; Medical Biochemistry;

   Abstract :  Most proteins must fold into their native conformations to fulfil their biological functions. Failure of proteins to fold leads to cell pathology and a broad range of human diseases referred to as protein misfolding disease, e.g., Alzheimer’s disease, Parkinson’s disease, and type II diabetes. READ MORE

4. 2. On protein structure, function and modularity from an evolutionary perspective

   Author : Robert Pilstål; Björn Wallner; Maria Sunnerhagen; Mauno Vihinen; Linköpings universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; structure; biology; intrinsical; disorder; protein; sequence; evolution; mutation; epistasis; function; allostery; dynamics; simulation; prediction; graph; network; bioinformatik; struktur; biologi; strukturbiologi; intrinsiellt; oordnad; protein; sekvens; evolution; mutation; epistasis; funktion; allosteri; dynamik; simulation; prediktion; graf; nätverk;

   Abstract : We are compounded entities, given life by a complex molecular machinery. When studying these molecules we have to make sense of a diverse set of dynamical nanostructures with wast and intricate patterns of interactions. READ MORE

5. 3. Antiadhesive agents targeting uropathogenic Escherichia coli : Multivariate studies of protein-protein and protein-carbohydrate interactions

   Author : Andreas Larsson; Jan Kihlberg; Fredrik Almqvist; Mats Larhed; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Antibacterial; pili; antiadhesive agents; structure based design; statistical molecular design; 2-pyridone; amino acid derivative; galabiose; enaminone; SPR; ELISA; QSAR; Organisk kemi; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

   Abstract : This thesis describes studies directed towards development of novel antiadhesive agents, with particular emphasis on compounds that prevent attachment of bacteria to a host-cell. Three different proteins involved in the assembly or function of adhesive pili in uropathogenic Escherichia coli have been targeted either by rational structure based design or statistical molecular methods. READ MORE

6. 4. Ribosomal Stalk Protein L12 : Structure, Function and Application

   Author : Chandra Sekhar Mandava; Suparna Sanyal; Knud Nierhaus; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Ribosome; protein synthesis; L12 dimer; initiation; elongation; G factors; and His-tag; Molecular biology; Molekylärbiologi; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

   Abstract : Ribosomal stalk proteins are known to play important role in protein synthesis. The ‘stalk’, an extended structure on the large subunit of the ribosome is composed mainly of two to three dimers of L12 and one L10 protein, which forms the base of the stalk. In E. READ MORE

7. 5. On the effects of structure and function on protein evolution

   Author : Kristoffer Illergård; Arne Elofsson; Nir Ben-Tal; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein; structure; function; evolution; membrane; Biochemistry; Biokemi; Biochemistry; biokemi;

   Abstract : Many proteins can be described as working machines that make sure that everything functions in the cell. Their specific molecular functions are largely dependent on their three-dimensional structures, which in turn are mainly predetermined by their linear sequences of amino acid residues. READ MORE