Search for dissertations about: "Protein modeling"

Showing result 1 - 5 of 169 swedish dissertations containing the words Protein modeling.

  1. 1. Physical Modeling of Protein Folding

    Author : Stefan Wallin; Beräkningsbiologi och biologisk fysik; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; relativity; quantum mechanics; classical mechanics; three-helix bundle; similarity measure; Mathematical and general theoretical physics; protein dynamics; protein folding; two-state; Matematisk och allmän teoretisk fysik; thermodynamics; statistical physics; gravitation; klassisk mekanik; kvantmekanik; relativitet; statistisk fysik; termodynamik; Fysicumarkivet A:2003:Wallin;

    Abstract : Sequence-based models for protein folding are developed and tested on peptides with both alpha- and beta-structure, and on small three-helix-bundle proteins. The interaction potentials of the models are minimalistic and based mainly on hydrogen bonding and effective hydrophobicity forces. READ MORE

  2. 2. Systems Biology of Protein Secretion in Human Cells: Multi-omics Analysis and Modeling of the Protein Secretion Process in Human Cells and its Application

    Author : Rasool Saghaleyni; Chalmers University of Technology; []
    Keywords : Erythropoietin; cancer protein secretory pathway; protein secretion modeling; HEK293; protein secretion; Integrative omics analysis; genome-scale modeling;

    Abstract : Since the emergence of modern biotechnology, the production of recombinant pharmaceutical proteins has been an expanding field with high demand from industry. Pharmaceutical proteins have constituted the majority of top-selling drugs in the pharma industry during recent years. READ MORE

  3. 3. Computational Protein Evolution : Modeling the Selectivity and Promiscuity of Engineered Enzymes

    Author : Klaudia Szeler; Shina C. Lynn Kamerlin; Mikael Widersten; Maria Ramos; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; enzymes; kinetics; catalysis; density functional theory; empirical valence bond; diesters; evolution; promiscuity; Biokemi; Biochemistry;

    Abstract : Enzymes are biological catalysts that significantly increase the rate of all biochemical reactions that take place within cells and are essential to maintain life. Many questions regarding their function remain unknown. READ MORE

  4. 4. Systems biology of protein synthesis and secretion in yeast

    Author : Qi Qi; Chalmers University of Technology; []
    Keywords : NATURVETENSKAP; TEKNIK OCH TEKNOLOGIER; NATURAL SCIENCES; ENGINEERING AND TECHNOLOGY; multi-omics analysis; protein synthesis; recombinant protein production; genome-scale modeling; protein secretion;

    Abstract : Protein synthesis and secretion is a vital process to maintain cell function. As it demands numerous building blocks, cofactors and chaperones generated from metabolism and translation, the process is intertwined with metabolic and regulatory networks. READ MORE

  5. 5. Ensemble methods for protein structure prediction

    Author : Marcin J. Skwark; Arne Elofsson; Michael Tress; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; protein structure prediction; model quality assessment; contact prediction; homology modeling; ab-initio prediction; consensus prediction; structural bioinformatics; bioinformatics; protein structure; biokemi; inriktning teoretisk kemi; Biochemistry with Emphasis on Theoretical Chemistry;

    Abstract : Proteins play an essential role in virtually all of life's processes. Their function is tightly coupled to the three-dimensional structure they adopt.Solving protein structures experimentally is a complicated, time- and resource-consuming endeavor. READ MORE