Search for dissertations about: "Protein profiling"

Showing result 1 - 5 of 206 swedish dissertations containing the words Protein profiling.

  1. 1. Antibody based plasma protein profiling

    University dissertation from Stockholm : KTH Royal Institute of Technology

    Author : Ulrika Qundos; KTH.; KTH.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein profiling; plasma; antibody; affinity proteomics; biomark- ers; multiplex; assay development;

    Abstract : This thesis is about protein profiling in serum and plasma using antibody suspension bead arrays for the analysis of biobanked samples and in the context of prostate cancer biomarker discovery. The influence of sample preparation methods on antibody based protein profiles were investigated (Papers I-III) and a prostate cancer candidate biomarker identified and verified (Papers III-V). READ MORE

  2. 2. Validation of antibodies for protein profiling A study using immunohistochemistry on tissue microarrays

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Linda Paavilainen; Uppsala universitet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antibody validation; monospecific antibodies; protein profiling; immunohistochemistry; tissue microarrays; western blot; fixatives; MEDICINE Morphology; cell biology; pathology Pathology; MEDICIN Morfologi; cellbiologi; patologi Patologi; Pathology; patologi;

    Abstract : The field of proteomics has rapidly expanded due to the completion of the human genome sequence. This thesis validates affinity-purified monospecific antibodies of polyclonal origin, for protein profiling in a broad spectrum of normal tissues and cells. READ MORE

  3. 3. Protein Profiling and Type 2 Diabetes

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Tea Sundsten; Uppsala universitet.; [2008]
    Keywords : Cell biology; Type 2 diabetes; Protein profiling; SELDI-TOF MS; Proteomics; Cellbiologi;

    Abstract : Type 2 diabetes mellitus (T2DM) is a heterogeneous disease affecting millions of people worldwide. Both genetic and environmental factors contribute to the pathogenesis. The disease is characterized by alterations in many genes and their products. READ MORE

  4. 4. DNA-Mediated Detection and Profiling of Protein Complexes

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Maria Hammond; Uppsala universitet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proximity ligation assay; Protein complexes; Protein interactions; Biomarkers; Prions; Antibodies; Medicinsk vetenskap; Medical Science;

    Abstract : Proteins are the effector molecules of life. They are encoded in DNA that is inherited from generation to generation, but most cellular functions are executed by proteins. Proteins rarely act on their own – most actions are carried out through an interplay of tens of proteins and other biomolecules. READ MORE

  5. 5. Proximity Ligation and Barcoding Assays Tools for analysis of proteins and protein complexes

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Di Wu; Uppsala universitet.; Uppsala universitet.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proximity ligation assay; proximity barcoding assay; sensitive; in situ; multiplex; profiling; amyloid-beta; MARK; tau; CSF; biomarker; protein complexes; Alzheimer’s disease; amyotrophic lateral sclerosis; Molekylär medicin; Molecular Medicine;

    Abstract : Proteins are fundamental structural, enzymatic and regulatory components of cells. Analysis of proteins, such as by measuring their concentrations, characterizing their modifications, and detecting their interactions, provides insights in how biological systems work physiologically or pathologically at the molecular level. READ MORE