Search for dissertations about: "Protein-ligand"

Showing result 11 - 15 of 46 swedish dissertations containing the word Protein-ligand.

  2. 11. Structural and functional studies of proteins of medical relevance : Protein-ligand complexes in cancer and novel structural folds in bacteria

    Author : Robert Gustafsson; Pål Stenmark; Pavlína Řezáčová; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; X-ray crystallography; Cancer; MTH1; oxidised nucleotides; MTHFD2; nucleotide metabolism; one-carbon metabolism; Botulism; Botulinum neurotoxin; OrfX; OrfX gene cluster; Biochemistry; biokemi;

    Abstract : X-ray crystallography is a tool for determining the structures of proteins and protein-ligand complexes. In this thesis the method has been employed to study several proteins of medical relevance.Cancer is a terrible disease, severely impacting those affected, as well as their family and friends. READ MORE

  4. 12. Analysis of noncovalent and covalent protein-ligand complexes by electrospray ionisation mass spectrometry

    Author : Gustav Sundqvist; Harry Brumer; Per Andrén; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; noncovalent complex; droplet fission; nano-electrospray ionisation; mass spectrometry; Analytical chemistry; Analytisk kemi;

    Abstract : In this thesis, the application of electrospray ionisation mass spectrometry (ESI-MS) to the analysis of intact proteins is demonstrated. In papers I and II, the use of ESI-MS for the analysis of noncovalent protein-ligand complexes were discussed. READ MORE

  5. 13. Exploring non-covalent interactions between drug-like molecules and the protein acetylcholinesterase

    Author : Lotta Berg; Anna Linusson; Fredrik Ekström; Joel L. Sussman; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; acetylcholinesterase; drug discovery; density functional theory; hydrogen bond; nerve-agent antidote; non-covalent interaction; protein-ligand complex; structure-based design; thermodynamics; X-ray crystallography; datorlingvistik; computational linguistics;

    Abstract : The majority of drugs are small organic molecules, so-called ligands, that influence biochemical processes by interacting with proteins. The understanding of how and why they interact and form complexes is therefore a key component for elucidating the mechanism of action of drugs. READ MORE

  6. 14. Touching the Essence of Life : Haptic Virtual Proteins for Learning

    Author : Petter Bivall; Anders Ynnerman; Lena A. E. Tibell; Matthew D. Cooper; Miriam Reiner; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Haptics; Educational Research; Biomolecular Education; Life Science; JND; Just Noticeable Difference; Protein-ligand Docking; Haptic docking; Visualization; Haptic Transfer Functions; Volume Data Haptics; History Dependent Transfer Function; Log file analysis; Molecular Recognition; Force Feedback; Virtual Reality; Other information technology; Övrig informationsteknik;

    Abstract : This dissertation presents research in the development and use of a multi-modal visual and haptic virtual model in higher education. The model, named Chemical Force Feedback (CFF), represents molecular recognition through the example of protein-ligand docking, and enables students to simultaneously see and feel representations of the protein and ligand molecules and their force interactions. READ MORE

  7. 15. Structure, dynamics and interactions of biomolecules : Investigations by NMR spectroscopy and computational methods

    Author : Jens Landström; Göran Widmalm; Pedro Nieto; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NMR spectroscopy; MD simulation; carbohydrate synthesis; protein-ligand interaction; glycosyltransferase; Chemistry; Kemi; organisk kemi; Organic Chemistry;

    Abstract : In this thesis, the structure, dynamics and interactions of proteins and carbohydrates are investigated using mainly NMR spectroscopy and computer simulations. Oligosaccharides representing a Salmonella O-antigen have been synthesized and their dynamic behavior and interaction with the bacteriophage P22 tail-spike protein have been studied by NMR spectroscopy, MD and docking simulations. READ MORE