Search for dissertations about: "Protein-ligand"
Showing result 16 - 20 of 46 swedish dissertations containing the word Protein-ligand.
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16. Assessment of Computational Methods for Ligand Binding
Abstract : Most drugs act on biomacromolecules. The Cost of developing new drugs is very high. A method to accurately predict binding affinities would be very useful. READ MORE
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17. Molecular basis for galectin-ligand interactions : Design, synthesis and analysis of ligands
Abstract : Galectins are a class of β-galactoside-binding proteins that bind glycoconjugates and have been implicated in cancer, regulation of immunity and inflammation. Design and synthesis have achieved highly potent and selective galectin ligands that can inhibit interactions with glycoproteins and have consequent cellular effects. READ MORE
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18. On the estimation of ligand binding affinities
Abstract : A method to accurately estimate the binding affinity of a small molecule to a receptor would be indispensable in numerous fields. For instance, most drugs exert their action by binding to a macromolecule target. Thus, a lot of time and resources could be saved in drug design by predicting affinities by computer programs. READ MORE
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19. Functional analysis of ligand recognition by the glucocorticoid receptor
Abstract : The glucocorticoid receptor (GR) is a ligand-inducible transcription factor that belongs to the superfamily of nuclear hormone receptors. It contains three structural and functional domains. READ MORE
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20. Structure and energetics of molecular recognition in galectin-3-ligand interactions
Abstract : Molecular recognition is the key aspect of any cellular and biological function. Two or more molecules interacting with each other cause the effects that drives various basic functions that are fundamental to cells. Be these protein-protein, protein-nucleic acid or protein-ligand interactions, they all play important roles in a cell. READ MORE