Search for dissertations about: "Protein-ligand"

Showing result 6 - 10 of 46 swedish dissertations containing the word Protein-ligand.

2. 6. Development of Proteochemometrics—A New Approach for Analysis of Protein-Ligand Interactions

   Author : Maris Lapins; Jarl Wikberg; Johan Gottfries; Uppsala universitet; []
   Keywords : Pharmaceutical pharmacology; chemometrics; QSAR; G-protein coupled receptors; Melanocortin receptors; protein-ligand interactions; Farmaceutisk farmakologi;

   Abstract : A new approach to analysis of protein-ligand interactions, termed proteochemometrics, has been developed. Contrary to traditional quantitative structure-activity relationship (QSAR) methods that aim to correlate a description of ligands to their interactions with one particular target protein, proteochemometrics considers many targets simultaneously. READ MORE

4. 7. Studies of protein structure, dynamics and protein-ligand interactions using NMR spectroscopy

   Author : Tobias Tengel; Göran Larsson; Maria Sunnerhagen; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; 19F NMR; 2S albumin; PapD; protein-ligand interaction; structure; TFE; Yersinia; YopD; allergy; amphipathic helix; Ber e 1; Brazil nut; dynamics; FimC; LcrH; NMR screening; Biophysics; Biofysik;

   Abstract : In the first part of the thesis, protein-ligand interactions were investigated using the chaperone LcrH, from Yersinia as target protein. The structure of a peptide encompassing the amphipathic domain (residue 278-300) of the protein YopD from Yersinia was determined by NMR in 40% TFE. READ MORE

5. 8. Chemogenomics: Models of Protein-Ligand Interaction Space

   Author : Helena Strömbergsson; Gerard J Kleywegt; Jarl E S Wikberg; Torgeir R Hvidsten; John Overington; Uppsala universitet; []
   Keywords : ;

   Abstract : The large majority of the currently used drugs are small molecules that interact with proteins. Understanding protein-ligand recognition is thus central to drug discovery and design. Improved experimental techniques have resulted in an immense growth of drug target information. READ MORE

6. 9. Computational Studies of Structures and Binding Properties of Protein-Ligand Complexes

   Author : Xu Wang; Yaoquan Tu; Lennart Nilsson; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Teoretisk kemi och biologi; Theoretical Chemistry and Biology;

   Abstract : Proteins are dynamic structural entities that are involved in many biophysical processes through molecular interactions with their ligands. Protein-ligand interactions are of fundamental importance for computer-aided drug discovery. READ MORE

7. 10. Dynamic Systems for Screening, Control and Identification of Protein-Ligand Interactions

   Author : Rikard Larsson; Olof Ramström; Michel R. Gagné; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Dynamic combinatorial chemistry; Dynamic kinetic combinatorial resolution; Catalytic screening; Transthiolesterification; Thiol disulfide interchange; Nitroaldol reaction; Lectins; Hydrolases; Dynamic self-inhibition; Organic chemistry; Organisk kemi;

   Abstract : Dynamic systems for screening, control and identification of different protein-ligand interactions are presented. Dynamic chemistry is used to produce new compounds/constituents in situ that can interact with a target molecule. Several entities can be introduced at the same time and interact with one another. READ MORE