Search for dissertations about: "Protein-protein interaction networks"

Showing result 1 - 5 of 13 swedish dissertations containing the words Protein-protein interaction networks.

2. 1. Exploration of analytical methods to study motif-mediated host-virus protein-protein interactions

   Author : Eszter Kassa; Ylva Ivarsson; Gilles Travé; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; protein-protein interaction; short linear motif; affinity purification-mass spectrometry; virus; SARS-CoV-2; TBEV; Analytical Chemistry; Analytisk kemi;

   Abstract : Proteins are responsible for countless processes in living creatures, but most often they do not perform these tasks alone. Rather, they engage in interactions with other proteins, creating whole protein-protein interaction (PPI) networks. READ MORE

4. 2. Investigations into the evolution of biological networks

   Author : Sara Light; Arne Elofsson; David Ussery; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; evolution; scale-free network; metabolism; protein-protein interactions; protein hubs; Theoretical chemistry; Teoretisk kemi;

   Abstract : Individual proteins, and small collections of proteins, have been extensively studied for at least two hundred years. Today, more than 350 genomes have been completely sequenced and the proteomes of these genomes have been at least partially mapped. The inventory of protein coding genes is the first step toward understanding the cellular machinery. READ MORE

5. 3. Visualizing Interacting Biomolecules In Situ

   Author : Irene Weibrecht; Ola Söderberg; Ulf Landegren; Banafshe Larijani; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proximity ligation; in situ PLA; padlock probe; rolling circle amplification; flow cytometry; in situ; single cell; single molecule; protein interaction; protein-DNA interaction; posttranslational modification; Molecular medicine; Molekylär medicin; Molekylär medicin; Molecular Medicine;

   Abstract : Intra- and intercellular information is communicated by posttranslational modifications (PTMs) and protein-protein interactions, transducing information over cell membranes and to the nucleus. A cells capability to respond to stimuli by several highly complex and dynamic signaling networks provides the basis for rapid responses and is fundamental for the cellular collaborations required in a multicellular organism. READ MORE

6. 4. Gene networks and modules in atherosclerosis

   Author : Jesper Lundström; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : In this thesis we are using global gene expression profiles to unravel functional gene networks and modules. The focus is atherosclerosis, a disease with manifestations in the artery wall where deposits of lipids accumulate and trigger immune responses causing the development of plaques, which upon rupture can lead to a myocardial infarction or stroke. READ MORE

7. 5. A Systems Biological Approach to Parkinson's Disease

   Author : Katharina F. Heil; Jeanette Hellgren Kotaleski; Olivia Eriksson; J. Douglas Armstrong; Oksana Sorokina; Nigel Williams; KTH; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s Disease; Neuroscience; Bioinformatics; Network Analysis; Computer Science; Datalogi;

   Abstract : Parkinson’s Disease (PD) is the second most common neurodegenerative disease in the Western world. Itshows a high degree of genetic and phenotypic complexity with many implicated factors, various diseasemanifestations but few clear causal links. Ongoing research has identified a growing number of molecularalterations linked to the disease. READ MORE