Search for dissertations about: "Protein"
Showing result 16 - 20 of 8290 swedish dissertations containing the word Protein.
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16. Human Aquaporins: Production, Characterization and Interactions
Abstract : Membrane proteins are essential components of the cell and responsible for the communication with the outside environment and transport of molecules across the membrane. Water transport is facilitated by aquaporins, which are water selective transmembrane pores that serve to maintain cell homeostasis. READ MORE
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17. Structural and thermodynamical basis for molecular recognition between engineered binding proteins
Abstract : The structural determination of interacting proteins, both as individual proteins and in their complex, complemented by thermodynamical studies are vital in order to gain in-depth insights of the phenomena leading to the highly selective protein-protein interactions characteristic of numerous life processes. This thesis describes an investigation of the structural and thermodynamical basis for molecular recognition in two different protein-protein complexes, formed between so-called affibody proteins and their respective targets. READ MORE
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18. Protein-Protein Interactions Affecting Protein-Surface Interactions
Abstract : The focus of this thesis is the behaviour of proteins towards surfaces in the presence of other protein species. General protein-protein interactions of some plasma proteins are investigated in the first four papers. The proteins, immunoglobulin G, albumin, and fibrinogen, are analysed in solutions of single proteins as well as controlled mixtures. READ MORE
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19. Protein-protein interactions in model systems : design, control of catalytic activity and biosensor applications
Abstract : This thesis describes the design of polypeptides, unordered in the monomeric state but capable of folding into helix-loop-helix motifs and dimerise to form four-helix bundles. The goal of the design was to encode them with the capacity to form dimers highly selectively and the ability to carry out molecular functions in the folded state but not in the unordered state, and thus to establish a molecular link between recognition and function. READ MORE
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20. From protein sequence to structural instability and disease
Abstract : A great challenge in bioinformatics is to accurately predict protein structure and function from its amino acid sequence, including annotation of protein domains, identification of protein disordered regions and detecting protein stability changes resulting from amino acid mutations. The combination of bioinformatics, genomics and proteomics becomes essential for the investigation of biological, cellular and molecular aspects of disease, and therefore can greatly contribute to the understanding of protein structures and facilitating drug discovery. READ MORE
