Search for dissertations about: "Protofibrils"
Showing result 16 - 18 of 18 swedish dissertations containing the word Protofibrils.
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16. Characterization of the novel “Uppsala mutation” causing a familial form of early onset Alzheimer’s disease
Abstract : The Alzheimer’s disease (AD) brain displays extracellular plaques of amyloid-β (Aβ), neurofibrillary tangles of tau and neuronal loss. The 40-42 amino acid Aβ peptide is formed from the amyloid precursor protein (APP) by β-secretase and γ-secretase, while α-secretase prevents Aβ generation. READ MORE
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17. Structural and functional properties of transthyretin
Abstract : The hereditary transthyretin (TTR) amyloidoses are rare, and in severe cases, fatal disorders caused by mutations in the TTR gene. The clinical picture is diverse, involving neuropathies and myopathies, and mainly depends on the causative mutation and the sites and rates of amyloid deposition. READ MORE
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18. Inflammatory proteins in the CNS-relation to Alzheimer's disease
Abstract : Most neurodegenerative disorders are characterised by an inflammatory process in the brain. Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common form of dementia in the elderly. Activated astrocytes and microglia surrounding the amyloid plaques represent evidence for neuroinflammation in the AD brain. READ MORE