Search for dissertations about: "Proximity Extension Assay"

Showing result 16 - 20 of 37 swedish dissertations containing the words Proximity Extension Assay.

2. 16. Antibody-based Cancer Immunotherapy : Personalization, response prediction and safety considerations

   Author : Mohamed Eltahir; Sara Mangsbo; Patrick Micke; Gustav Ullenhag; Marit Inderberg; Uppsala universitet; []
   Keywords : ;

   Abstract : Antibody-based therapeutics have remarkably improved the field of immuno-oncology. Multiple monoclonal antibodies (mAbs) are approved for clinical use, and numerous antibodies are under clinical development. The scope of this thesis is to study the personalization of antibody-based immunotherapeutics and tools to predict their efficacy and safety. READ MORE

4. 17. Targeted multiplex proteomics for risk stratification in patients with cardiovascular disease

   Author : Emma Skau; Pär Hedberg; Jerzy Leppert; Johan Ärnlöv; Eva Swahn; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cardiovascular disease; proteomics; myocardial infarction; peripheral arterial disease; biomarker; GDF-15; Cardiology; Kardiologi;

   Abstract : Risk stratification is valuable in patients with cardiovascular disease (CVD). Proteins involved in different pathophysiological processes in atherosclerosis have shown prognostic capacity. A new technology, Proximity Extension Assay (PEA), enables the simultaneous analysis of numerous plasma proteins from a minimal amount of plasma. READ MORE

5. 18. Exploring Links between Melatonin, Inflammation and Depression

   Author : Isak Sundberg; Janet Cunningham; Lisa Ekselius; Daniel Lindqvist; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; melatonin; inflammation; depression; biomarkers; cytokines; anxiety; hepatitis C; Psychiatry; Psykiatri;

   Abstract : Major depressive disorder (MDD) is one of the leading global causes of disease burden. Worse yet, about one third of the patients with MDD do not experience a remission with current treatments. READ MORE

6. 19. Immunologic Markers in the Tumor Microenvironment of Classical Hodgkin Lymphoma

   Author : Alex R. Gholiha; Gunilla Enblad; Rose-Marie Amini; Peter Hollander; Gustaf Hedström; Arjan Diepstra; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tumor microenvironment; immunohistochemistry; immune checkpoints; Plasma cells; IL-6 cytokine; Proteomics; CD47.;

   Abstract : In classical Hodgkin lymphoma (cHL), cytokine regulation and cellular composition of the tumor microenvironment (TME) is crucial for tumor cell survival. In paper I, we examined the presence of CD138+ plasma cells and IgG4+ plasma cells in diagnostic cHL biopsies with immunohistochemistry (IHC). READ MORE

7. 20. Influence of bone-associated and cardiovascular biomarkers on vascular events and mortality in relation to renal dysfunction

   Author : Ping-Hsun Wu; Östen Ljunggren; Bengt Fellström; Torbjörn Linde; Jonas Spaak; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; biomarkers; bone markers; cardiovascular markers; proteomics; vascular event; mortality; renal function; hemodialysis; Medicinsk vetenskap; Medical Science;

   Abstract : Biomarkers can help physicians identify subjects with an increased cardiovascular risk. Apart from the clinical factors, some biomarkers have been recognized as important predictors and risk factors for cardiovascular disease in renal disease. READ MORE