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Showing result 1 - 5 of 632 swedish dissertations matching the above criteria.

2. 1. Proximity Ligation : Transforming protein analysis into nucleic acid detection through proximity-dependent ligation of DNA sequence tagged protein-binders

   Author : Simon Fredriksson; Larry Gold; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular medicine; Proximity ligation; proteomics; SELEX; antibody; DNA microarray; Molekylärmedicin; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; Molecular Medicine; molekylär medicin genetik och patologi ;

   Abstract : A novel technology for protein detection, proximity ligation, has been developed along with improved methods for in situ synthesis of DNA microarrays. Proximity ligation enables a specific and quantitative transformation of proteins present in a sample into nucleic acid sequences. READ MORE

4. 2. Proximity and Learning in Internationalisation : Small Swedish IT firms in India

   Author : Kristina Westermark; Brita Hermelin; Charlotta Hedberg; Andrew Jones; Stockholms universitet; []
   Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Internationalisation; proximity; learning; communities of practice; India; Sweden; ICT; service; IT; small firms; Human Geography; kulturgeografi;

   Abstract : The four IT service firms of this thesis set out to interact and collaborate between their offices in Sweden and in India, some more intensely and frequently than others. In the process of their internationalisation, these small service firms find ways, or go through a process of learning how to collaborate in an international setting. READ MORE

5. 3. Proximity Extension Assay : a universal tool for proteomics in precision medicine

   Author : Phathutshedzo M. Muthelo; Ulf Landegren; Jochen Schwenk; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proximity Extension Assay; Precision medicine; Assay development; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

   Abstract : Precision medicine aims to utilise biomarkers to ensure the right treatment is given to the right patient at the right time. In pursuit of this goal, sensitive protein detection is essential to improve opportunities for discovery, verification, validation and development of valuable protein biomarkers. READ MORE

6. 4. The accessibility paradox : Everyday geographies of proximity, distance and mobility

   Author : Katarina Haugen; Kerstin Westin; Einar Holm; Örjan Pettersson; David Banister; Umeå universitet; []
   Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Accessibility; proximity; distance; daily mobility; everyday life; residential conditions; spatial structure;

   Abstract : This thesis aims to explore the importance of proximity and mobility, respectively, for individuals’ accessibility, as well as the relationship between these two key spatial dimensions of accessibility in the context of everyday life. The thesis is based upon three empirical research papers which focus on accessibility-related preferences, actual accessibility conditions, and travel patterns. READ MORE

7. 5. Proximity Ligation and Barcoding Assays : Tools for analysis of proteins and protein complexes

   Author : Di Wu; Masood Kamali-Moghaddam; Ulf Landegren; Ola Söderberg; Jörg Hoheisel; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proximity ligation assay; proximity barcoding assay; sensitive; in situ; multiplex; profiling; amyloid-beta; MARK; tau; CSF; biomarker; protein complexes; Alzheimer’s disease; amyotrophic lateral sclerosis; Molekylär medicin; Molecular Medicine;

   Abstract : Proteins are fundamental structural, enzymatic and regulatory components of cells. Analysis of proteins, such as by measuring their concentrations, characterizing their modifications, and detecting their interactions, provides insights in how biological systems work physiologically or pathologically at the molecular level. READ MORE