Search for dissertations about: "Purine"

Showing result 1 - 5 of 57 swedish dissertations containing the word Purine.

  2. 1. Purine and Pyrazolopyrimidine Derivatives: Design and Synthesis of Chemical Tools for Biological Applications

    Author : David Bliman; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; purine; pyrazolopyrimidine; caged compounds; protein kinases; protein-protein interactions; fluorescence; organic synthesis;

    Abstract : Purines can be found in a multitude of naturally occurring compounds with a range of functions. This thesis describes the design and synthesis of purines and structurally related pyrazolopyrimidine derivatives intended for biological applications. READ MORE

  4. 2. Inhibition of the MDM2/p53 Interaction Design, Synthesis and Evaluation of MDM2 Inhibitors

    Author : Mariell Pettersson; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Protein-protein interactionProtein-protein interaction; MDM2 p53 interaction; MDM2 inhibitors; α- helix mimetics; β-hairpin; 2; 5-diketopiperazine; spiro-2; 5-diketopiperazine; purine; 8- triazolyl purine; solution conformational analysis; NAMFIS; fluorescence;

    Abstract : Numerous essential cellular processes are regulated by protein-protein interactions (PPIs) and PPIs have therefore been recognised as potential new drug targets. The transcription factor p53 is often referred to as the guardian of the genome due to its involvement in DNA repair, induction of cell cycle arrest and cellular apoptosis. READ MORE

  5. 3. Vascular Effects of P2 Receptors. Changes in Congestive Heart Failure

    Author : Malin Malmsjö; Lund Medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; congestive heart failure; pyrimidine; purine; P2 receptor; vasodilatation; vasoconstriction; hyperpolarisation; EDHF; NO; Vascular; endothelium; Cardiovascular system; Kardiovaskulära systemet;

    Abstract : Extracellular nucleotides induce dilatation and constriction of blood vessels by activation of P2 receptors. In this thesis the vasomotor effects of P2 receptor activation were studied in the rat mesenteric artery, and their changes in congestive heart failure (CHF) were evaluated using in vitro pharmacology, electrophysiology and competitive RT-PCR. READ MORE

  6. 4. Purine synthesis inhibition in experimental lupus

    Author : Charlotte A Jonsson; Göteborgs universitet; []
    Keywords : SLE; Mycophenolate mofetil; MRLlpr lpr mice; cytokine; autoantibody;

    Abstract : Systemic lupus erythematosus (SLE) is an autoimmune disease that mainly affects women. The effect of the immune modulating drug mycophenolate mofetil (MMF) on experimental SLE was investigated. READ MORE

  7. 5. Experimental and clinical studies on human purine metabolism

    Author : Frank Niklasson; Uppsala universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : .... READ MORE