Search for dissertations about: "Q-ToF"

Found 5 swedish dissertations containing the word Q-ToF.

  1. 1. Selectivity in NMR and LC-MS Metabolomics : The Importance of Sample Preparation and Separation, and how to Measure Selectivity in LC-MS Metabolomics

    Author : Albert Elmsjö; Curt Pettersson; Torbjörn Arvidsson; Thomas Moritz; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; Metabolomics; NMR; LC-MS; HILIC; UHPLC; Q-ToF; selectivity; co-feature ratio; method evaluation; data evaluation; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Abstract : Until now, most metabolomics protocols have been optimized towards high sample throughput and high metabolite coverage, parameters considered to be highly important for identifying influenced biological pathways and to generate as many potential biomarkers as possible. From an analytical point of view this can be troubling, as neither sample throughput nor the number of signals relates to actual quality of the detected signals/metabolites. READ MORE

  2. 2. Development of Methods for the Analysis of Polar Compounds in Environmental Matrices using LC/UV and LC/MS

    Author : Johanna Minten; Margaretha Adolfsson-Erici; Leif Kronberg; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; Applied Environmental Science; tillämpad miljövetenskap;

    Abstract : In recent years, the awareness of environmentally hazardous compounds with polar and ionizable properties has intensified. Pharmaceuticals, the pesticide tebuconazole as well as the artificial sweetener sucralose are examples of such new, emerging, contaminants. READ MORE

  3. 3. Development of Methods in CE, CE-MS and MS/MS : Applications in Pharmaceutical, Biomedical and Forensic sciences

    Author : Emmy Jäverfalk-Hoyes; Jonas Bergquist; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; analytisk farmaceutisk kemi; Analytical Pharmaceutical Chemistry;

    Abstract : Capillary electrophoresis-mass spectrometry has been used successfully for the analysis of a wide range of analytes such as chiral local anaesthetics, sulphonated reactive dyes and endogenous neurotransmitters and neuropeptides.The partial filling technique was used in CE-MS for chiral separation of bupivacaine and ropivacaine using the non-volatile selector β-cyclodextrin. READ MORE

  4. 4. Structural Determination of Drug Metabolites from Doping Classed Compounds Using Mass Spectrometry

    Author : Annelie Hansson; Mikael Hedeland; Ulf Bondesson; Peter Hemmersbach; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mass spectrometry; UHPLC-MS MS; doping control; Cunninghamella elegans; selective androgen receptor modulator; SARM; andarine; ostarine; LGD-4033; roxadustat; HIF stabilizer; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Abstract : Doping control in equine sports is important for a fair competition, but also to ensure the integrity of the betting system, as well as for animal welfare reasons. To detect the use of illicit compounds, screening for the parent compound is common. However, by using a metabolite as the analytical target instead, the detection time can be prolonged. READ MORE

  5. 5. Purification, structure and function of bioactive peptides

    Author : Elo Eriste; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Peptides are vitally important molecules and many evoke cellular responses. The completion of several genome sequencing projects has revealed a number of new genes. READ MORE