Search for dissertations about: "QSAR analysis"
Showing result 1 - 5 of 23 swedish dissertations containing the words QSAR analysis.
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1. A multivariate approach to QSAR
Abstract : Quantitative structure-activity relationships (OSAR) constitute empirical analogy models connecting chemical structure and biological activity. The analogy approach to QSAR assume that the factors important in the biological system also are contained in chemical model systems.The development of a QSAR can be divided into subproblems:1. READ MORE
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2. Deciphering sequence data : A multivariate approach
Abstract : In this thesis, attention has been focused on the quantitative description of nucleic acids, proteins and peptides. The strategy was to use multivariate chemometrical methods for improving the understanding of the complex structural codes of these kinds of biological molecules. READ MORE
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3. Environmental Modeling and Uncertainty
Abstract : Environmental fate models are used to evaluate the fate and effects of chemicals for risk assessment. Fate models may be effective and low-cost substitutes for field measurements and are helpful to project future scenarios. READ MORE
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4. Chimeric gene delivery vectors : Design, synthesis, and mechanisms from transcriptomics analysis
Abstract : Delivery of nucleic acid is a promising approach for genetic diseases/disorders. However, gene therapy using oligonucleotides (ONs) suffers from low transfection efficacy due to negative charges, weak cellular permeability, and enzymatic degradation. READ MORE
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5. Development of Proteochemometrics—A New Approach for Analysis of Protein-Ligand Interactions
Abstract : A new approach to analysis of protein-ligand interactions, termed proteochemometrics, has been developed. Contrary to traditional quantitative structure-activity relationship (QSAR) methods that aim to correlate a description of ligands to their interactions with one particular target protein, proteochemometrics considers many targets simultaneously. READ MORE