Search for dissertations about: "QTc"

Showing result 1 - 5 of 12 swedish dissertations containing the word QTc.

  2. 1. Pharmacokinetic, efficacy and safety modeling of new treatments against drug-resistant tuberculosis

    Author : Lénaïg Tanneau; Mats Karlsson; Elin Svensson; Italo Poggesi; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; pharmacodynamics; pharmacometrics; nonlinear mixed effect models; tuberculosis; drug-resistance; bedaquiline; delamanid; metabolite; drug-drug interactions; QTc interval; transaminases; time-to-positivity; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Tuberculosis (TB) is an ancient infectious disease that remains one of the greatest killers on the planet. Its eradication is impeded by the development of resistance to first-line treatment. Each year half a million patients are infected with drug-resistant (DR) TB. READ MORE

  4. 2. Microvascular Complications and Predictors for Mortality in Patients with Type 2 Diabetes and Foot Ulcers

    Author : Katarina Fagher; Lund Medicin; []
    Keywords : Diabetic foot ulcer; Microvascular disease; mortality risk;

    Abstract : A diabetic foot ulcer (DFU) is a common and serious complication of diabetes. It is today the leading cause of amputations and is associated with both increased morbidity and mortality. Individuals with DFU have 2.5 times higher mortality rates compared to patients with diabetes but without DFU, a risk that persists even after ulcer healing. READ MORE

  5. 3. Improving assessment of cardiovascular arrhythmic safety of new pharmacologic agents

    Author : Lars Johannesen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Fourteen drugs have been removed from the market worldwide due to an increased risk of torsade de pointes (TdP), a potentially fatal ventricular arrhythmia. Almost all of the removed drugs that have been linked to an increased risk for TdP have been shown to block the human ether-à-go-go-related gene (hERG) potassium channel. READ MORE

  6. 4. Risks and risk monitoring in sotalol therapy for atrial fibrillation

    Author : Hanna Lenhoff; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: Atrial fibrillation (AF) stands as the most prevalent arrhythmia, significantly impacting both the prognosis and symptomatology of affected individuals. Healthcare expenditures associated with AF treatment and its related complications, in terms of morbidity and mortality, are substantial. READ MORE

  7. 5. Cardiovascular aspects on chronic obstructive pulmonary disease : with focus on ischemic ECG abnormalities, QT prolongation and arterial stiffness

    Author : Ulf Nilsson; Anne Lindberg; Anders Blomberg; Bengt Johansson; Christine Brulin; Per Bakke; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epidemiology; COPD; ischemic heart disease; cardiovascular disease; ECG; spirometry; kardiologi; Cardiology;

    Abstract : Background: Chronic Obstructive Pulmonary disease (COPD) is an under-diagnosed disease with a prevalence of approximately 10%, highly dependent on age and smoking habits. Comorbidities are common in COPD and of these, cardiovascular diseases (CVD) are the most common. READ MORE