Search for dissertations about: "Qinzi Yan"

Found 1 swedish dissertation containing the words Qinzi Yan.

  1. 1. Identification and characterization of small molecules targeting MYC function

    University dissertation from Stockholm : Karolinska Institutet, Dept of Microbiology, Tumor and Cell Biology

    Author : Qinzi Yan; Karolinska Institutet.; Karolinska Institutet.; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The MYC family genes (c-, N- and L-MYC) encode potent oncoproteins/transcription factors regulating fundamental cellular processes involved in cell proliferation, metabolism and survival, and they play an important role in tumor development. Overexpression of MYC often induce apoptosis as a failsafe mechanism to prevent tumor development and it is known to sensitize cells to genotoxic agents that induce DNA damage by triggered apoptosis. READ MORE