Advanced search

Found 1 swedish dissertation matching the above criteria.

2. 1. Identification and characterization of small molecules targeting MYC function

   Author : Qinzi Yan; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The MYC family genes (c-, N- and L-MYC) encode potent oncoproteins/transcription factors regulating fundamental cellular processes involved in cell proliferation, metabolism and survival, and they play an important role in tumor development. Overexpression of MYC often induce apoptosis as a failsafe mechanism to prevent tumor development and it is known to sensitize cells to genotoxic agents that induce DNA damage by triggered apoptosis. READ MORE