Search for dissertations about: "Qtc"

Showing result 1 - 5 of 7 swedish dissertations containing the word Qtc.

  1. 1. Microvascular Complications and Predictors for Mortality in Patients with Type 2 Diabetes and Foot Ulcers

    University dissertation from Lund University: Faculty of Medicine

    Author : Katarina Fagher; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetic foot ulcer; Microvascular disease; mortality risk;

    Abstract : A diabetic foot ulcer (DFU) is a common and serious complication of diabetes. It is today the leading cause of amputations and is associated with both increased morbidity and mortality. Individuals with DFU have 2.5 times higher mortality rates compared to patients with diabetes but without DFU, a risk that persists even after ulcer healing. READ MORE

  2. 2. Improving assessment of cardiovascular arrhythmic safety of new pharmacologic agents

    University dissertation from Stockholm : Karolinska Institutet, Dept of Molecular Medicine and Surgery

    Author : Lars Johannesen; Karolinska Institutet.; Karolinska Institutet.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Fourteen drugs have been removed from the market worldwide due to an increased risk of torsade de pointes (TdP), a potentially fatal ventricular arrhythmia. Almost all of the removed drugs that have been linked to an increased risk for TdP have been shown to block the human ether-à-go-go-related gene (hERG) potassium channel. READ MORE

  3. 3. Cardiovascular aspects on chronic obstructive pulmonary disease with focus on ischemic ECG abnormalities, QT prolongation and arterial stiffness

    University dissertation from Umeå : Umeå University

    Author : Ulf Nilsson; Anne Lindberg; Anders Blomberg; Bengt Johansson; Christine Brulin; Per Bakke; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epidemiology; COPD; ischemic heart disease; cardiovascular disease; ECG; spirometry; kardiologi; Cardiology;

    Abstract : BackgroundChronic Obstructive Pulmonary disease (COPD) is an under-diagnosed disease with a prevalence of approximately 10%, highly dependent on age and smoking habits. Comorbidities are common in COPD and of these, cardiovascular diseases (CVD) are the most common. READ MORE

  4. 4. Long QT syndrome in Sweden founder effects and associated cardiac phenotypes

    University dissertation from Umeå : Umeå universitet

    Author : Annika Winbo; Umeå universitet.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Long QT Syndrome; Jervell and Lange-Nielsen Syndrome; inherited arrhythmia; founder effects; clinical genetics; haplotype analysis; mutation age; founder mutation; clinical phenotype; life-threatening cardiac events; mutation-specific; KCNQ1 gene; modifier genes; sequence variants; risk stratification; risk factor; gender; Pediatrics; pediatrik;

    Abstract : Background: We aimed to increase the knowledge regarding the familial arrhythmogenic disorder Long QT Syndrome (LQTS) and its recessive variant Jervell and Lange-Nielsen Syndrome (JLNS) in Sweden, including prevalences and clinical phenotypes. A specific focus was directed towards two KCNQ1 mutations –p.Y111C and p. READ MORE

  5. 5. Role of the hERG-channel in arrhythmia and teratogenicity. Studies in animal models and the human embryonic heart

    University dissertation from Stockholm : Karolinska Institutet, Department of Medicine at Huddinge University Hospital

    Author : Christian Danielsson; Karolinska Institutet.; Karolinska Institutet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Background: Drugs that inhibit cardiac repolarization are associated with potentially life threatening side effects in the form of ventricular arrhythmias in humans. Animal studies show that this mechanism also is relevant for the embryo, and that the circulatory depression results in hypoxia with embryotoxicity in the form of malformations and death as a consequence. READ MORE