Search for dissertations about: "Qtc"

Showing result 6 - 10 of 12 swedish dissertations containing the word Qtc.

2. 6. Myocardial electromechanical function in long QT syndrome

   Author : Dafni Charisopoulou; Michael Y. Henein; Annika Rydberg; Anders Jonzon; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Long QT syndrome; stress-echocardiography; left ventricular filling; mechanical dispersion; diastolic myocardial function; exercise; arrhythmia; electromechanical window; speckle-tracking echocardiography; myocardial relaxation sequence.; kardiologi; Cardiology; cardiovascular disease; hjärt- och kärlforskning;

   Abstract : AIM: The aim of this thesis is to assess, in LQTS and according to genotype, the myocardial electromechanical (EM) function response to exercise, its relation to symptoms and its response to b-blocker therapy. To achieve this aim, we conducted 4 studies with the following specific objectives: i. READ MORE

4. 7. Repolarization studies in the long QT syndrome

   Author : Pia Dahlberg; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; long QT syndrome; repolarization; hysteresis; vectorcardiography; QT adaptation; ventricular repolarization;

   Abstract : ABSTRACT Background: Sudden cardiac death in the young is predominantly caused by inherited cardiac conditions. Long QT syndrome (LQTS) is one of the most common of these disorders. Since risk stratification relies largely upon the heart rate (HR) corrected QT interval (QTc), it is crucial to identify an appropriate method for QT correction. READ MORE

5. 8. Applications of Vectorcardiography for Diagnosis and Risk Stratification in Subpopulations at Risk for Life-Threatening Arrhythmias

   Author : Daniel Cortez; Kardiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vectorcardiography; atrial depolarization; ventricular depolarization repolarization;

   Abstract : Introduction: Vectorcardiography, or 3-dimensional electrocardiography is a tool which can be used to identify subtle changes in the electrical forces of the heart, and which can be applied to atrial depolarization, ventricular depolarization and ventricular repolarization for prognostic and diagostic purposes. Methods: Kor’s regression-related and quasi orthogonal methods was used to derive vectorcardiographic parameters from the 12-lead electrocardiogram and applied to a cohort of cryptogenic stroke patients to assess atrial fibrillation, hypertrophic cardiomyopathy patients to assess for ventricular arrhythmias, applied with right-precordial directed quasi orthogonal method to arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC/D) patients for diagnosis, and applied to ventricular repolarization only to patients with genotype-positive/phenotype-negative Long QT2 syndrome (KNCH2 mutation) to assess for cardiac events. READ MORE

6. 9. Long QT syndrome in Sweden : founder effects and associated cardiac phenotypes

   Author : Annika Winbo; Annika Rydberg; Eric Schulze-Bahr; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Long QT Syndrome; Jervell and Lange-Nielsen Syndrome; inherited arrhythmia; founder effects; clinical genetics; haplotype analysis; mutation age; founder mutation; clinical phenotype; life-threatening cardiac events; mutation-specific; KCNQ1 gene; modifier genes; sequence variants; risk stratification; risk factor; gender; pediatrik; Pediatrics;

   Abstract : Background: We aimed to increase the knowledge regarding the familial arrhythmogenic disorder Long QT Syndrome (LQTS) and its recessive variant Jervell and Lange-Nielsen Syndrome (JLNS) in Sweden, including prevalences and clinical phenotypes. A specific focus was directed towards two KCNQ1 mutations –p.Y111C and p. READ MORE

7. 10. Role of the hERG-channel in arrhythmia and teratogenicity : studies in animal models and the human embryonic heart

   Author : Christian Danielsson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Background: Drugs that inhibit cardiac repolarization are associated with potentially life threatening side effects in the form of ventricular arrhythmias in humans. Animal studies show that this mechanism also is relevant for the embryo, and that the circulatory depression results in hypoxia with embryotoxicity in the form of malformations and death as a consequence. READ MORE