Search for dissertations about: "Quantitative trait loci QTL"

Showing result 21 - 25 of 61 swedish dissertations containing the words Quantitative trait loci QTL.

  2. 21. Type 2 Diabetes Genes Contributing to Insulin Secretion Defects

    Author : Charlotte Granhall; Genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sekretion; Endokrinologi; exocytosis; GK rat; NIDDM1I; genetics; gene expression; quantitative trait analysis; Sorcs1; Adra2a; Endocrinology; diabetology; insulin secretion; diabetologi; secreting systems; Type 2 diabetes;

    Abstract : Type 2 diabetes is caused by a combination of environmental and inherited factors influencing the progression of insulin resistance and impaired insulin secretion leading to chronically elevated blood glucose levels. The aim of this thesis was to functionally and genetically characterise the species-conserved diabetes locus Niddm1i of the GK rat encoding hyperglycaemia and defect insulin secretion. READ MORE

  4. 22. Quantitative Genetics and Genomic Selection of Scots pine

    Author : Ainhoa Calleja-Rodriguez; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Abstract : The final objective of tree improvement programs is to increase the frequency of favourable alleles in a population, for the traits of interest within the breeding programs. To achieve this, it is crucial to decompose the phenotypic variance accurately into its genetic and environmental components in order to obtain a precise estimation of genetic parameters and to increase genetic gains. READ MORE

  5. 23. Genetic dissection of quantitative traits in Scots pine

    Author : Sara Abrahamsson; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : The phenotypic expressions of Scots pine, have been extensively studied over the years, but the gene regulation behind the traits has only just begun to be elucidated. The overall aim of this thesis was to start dissecting the genetics behind a number of adaptive traits in Scots pine and examine how they are influenced by relatedness using different molecular tools. READ MORE

  6. 24. Novel strategies to explore The complex genetics of autoimmune diseases

    Author : Martina Johannesson; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Immunology; serology; Immunologi; serologi; cytogenetik; Genetik; cytogenetics; Genetics; collagen induced arthritis; QTL mapping; complex traits; autoimmunity; genetics;

    Abstract : Autoimmune diseases are dependent on both genetic and environmental factors in complex interplay. They arise from a faulty immune response against self-antigens, and causes great suffering in affected individuals. Despite large efforts and hundreds of thousands of research articles published, the disease etiologies remain largely unknown. READ MORE

  7. 25. Selection during Early Life Stages and Local Adaptation in Arabidopsis thaliana

    Author : Froukje M. Postma; Jon Ågren; Kathleen Donohue; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Dormancy cycling; Germination timing; Maternal effects; Natural variation; QTL mapping; Seed bank; Seed dormancy; Structural Equation Modeling; Biology with specialization in Ecological Botany; Biologi med inriktning mot ekologisk botanik;

    Abstract : Organisms are often adapted to their local environment, but the role of early life stages in adaptive differentiation among populations remains poorly known. The aim of my thesis was to investigate the contribution of early life stages to the magnitude and genetic basis of local adaptation, and to identify the underlying adaptive traits. READ MORE