Search for dissertations about: "Quantitative trait loci QTL"

Showing result 6 - 10 of 61 swedish dissertations containing the words Quantitative trait loci QTL.

  2. 6. Numerical Algorithms for Mapping of Multiple Quantitative Trait Loci in Experimental Populations

    Author : Kajsa Ljungberg; Sverker Holmgren; Örjan Carlborg; Margot Gerritsen; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Scientific computing; Beräkningsvetenskap; Scientific Computing;

    Abstract : Most traits of medical or economic importance are quantitative, i.e. they can be measured on a continuous scale. Strong biological evidence indicates that quantitative traits are governed by a complex interplay between the environment and multiple quantitative trait loci, QTL, in the genome. READ MORE

  4. 7. FROM DISEASE TO THE GENE - Identification of arthritis-regulating loci in rats

    Author : Carola Rintisch; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pristane-induced arthritis; Rat strain; Autoimmunity; Rheumatoid arthritis; Quantitative trait locus;

    Abstract : Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the peripheral joints that eventually leads to cartilage destruction and bone erosion. The causes of RA remain largely unknown, but considerable evidence suggests a multifactorial aetiology involving both environmental and genetic factors. READ MORE

  5. 8. An e-Science Approach to Genetic Analysis of Quantitative Traits

    Author : Mahen Jayawardena; Sverker Holmgren; Erwin Laure; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; QTL Analysis; Grid Computing; Global Optimization; e-Science; Beräkningsvetenskap; Scientific Computing;

    Abstract : Many important traits in plants, animals and humans are quantitative, and most such traits are generally believed to be affected by multiple genetic loci. Standard computational tools for mapping of quantitative traits (i.e. READ MORE

  6. 9. Genetic analysis of autoimmune diseases using animal models : Mapping susceptibility genes for multiple sclerosis and rheumatoid arthritis

    Author : Hai-Tao Yang; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Collagen induced arthritis CIA ; Experimental allergic encephalomyelities EAE ; Multiple sclerosis MS ; Quantitative trait loci QTL ; Rheumatoid arthritis RA ; Linkage analysis; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

    Abstract : Autoimmune diseases such as rheumatoid arthritis and multiple sclerosis are common human diseasesaffecting 1% and 0.1% of the population respectively. These diseases are characterized by abnormal self-tolerance in the immune system and autoimmune reactions. READ MORE

  7. 10. Functional Genomics of Bone Metabolism : Novel Candidate Genes Identified by Studies in Chicken Models

    Author : Carl-Johan Rubin; Andreas Kindmark; Östen Ljunggren; Leif Andersson; David Burt; Uppsala universitet; []
    Keywords : Molecular medicine; QTL; Bone; Osteoporosis; Gene expression; Microarray; Domestication; Molekylärmedicin;

    Abstract : Osteoporosis is a disease that leads to decreased bone mineral density (BMD), an altered bone micro-architecture and fragile bones. The disease is highly heritable and numerous genes are thought to be involved, making it difficult to identify the causative genetic elements. READ MORE