Search for dissertations about: "Quantitative trait locus"

Showing result 16 - 20 of 36 swedish dissertations containing the words Quantitative trait locus.

  2. 16. Defining the genetics of systemic autoimmunity in mouse models of lupus

    Author : Katarina Haraldsson; Kristina Lejon; Dwight Kono; Chandra Mohan; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; SLE; susceptibility; HgIA; genome-wide mapping; Lbw2; Lmb1-4; suppressing gene; Immunology; Immunologi;

    Abstract : Systemic Lupus Erythematosus (SLE) is a chronic multi-organ autoimmune disease considered a prototype for autoantibody and immune complex-mediated tissue injury. Although autoantibodies against a wide diversity of self-antigens are characteristically found in this disease, an important hallmark is the presence of autoantibodies to nuclear antigens. READ MORE

  4. 17. Identification of Arthritis Susceptibility Genes in Mice and Humans

    Author : Emma Ahlqvist; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunologi; transplantation; serology; Immunology; Medicin människa och djur ; Medicine human and vertebrates ; Biomedicinska vetenskaper; QTL; Biomedical sciences; Rheumatoid arthritis; Collagen-induced arthritis; serologi; Skeleton; muscle system; rheumatology locomotion; Skelett; muskelsystem; reumatologi; Clinical genetics; Klinisk genetik;

    Abstract : Rheumatoid arthritis (RA) is a chronic autoimmune disease with a largely unknown aetiology. The risk of developing RA is partly dependent on genetic factors, which has motivated extensive efforts to identify the disease regulating genes as away to understand disease pathogenesis. READ MORE

  5. 18. Dissecting the genetics of athletic performance and conformation traits in horses

    Author : Maria Rosengren; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : The overall aims of this thesis were to investigate the genetics of athletic performance and the level of inbreeding in Coldblooded trotters, as well as the genetics of conformation traits in Icelandic horses. In paper I, genomic-based inbreeding coefficients in Coldblooded trotters were estimated and compared with pedigree-based coefficients. READ MORE

  6. 19. Novel strategies to explore The complex genetics of autoimmune diseases

    Author : Martina Johannesson; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Immunology; serology; Immunologi; serologi; cytogenetik; Genetik; cytogenetics; Genetics; collagen induced arthritis; QTL mapping; complex traits; autoimmunity; genetics;

    Abstract : Autoimmune diseases are dependent on both genetic and environmental factors in complex interplay. They arise from a faulty immune response against self-antigens, and causes great suffering in affected individuals. Despite large efforts and hundreds of thousands of research articles published, the disease etiologies remain largely unknown. READ MORE

  7. 20. Development of Variance Component Methods for Genetic Dissection of Complex Traits

    Author : Francois Besnier; Örjan Calborg; Miguel Perez-Enciso; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bioinformatics; Bioinformatik; Genetik; Genetics;

    Abstract : This thesis presents several developments on Variance component (VC) approach for Quantitative Trait Locus (QTL) mapping. The first part consists of methodological improvements: a new fast and efficient method for estimating IBD matrices, have been developed. READ MORE