Search for dissertations about: "R6 2 mice"

Found 5 swedish dissertations containing the words R6 2 mice.

  1. 1. Brown is the new white: consequences of white adipose tissue alterations in Huntington's disease

    University dissertation from Lund University, Faculty of Medicine

    Author : Andy Mccourt; Lunds universitet.; Lund University.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Huntington’s disease; weight loss; white adipose tissue; brown adipose tissue; peripheral symptoms; R6 2 mice; UCP1; CREB1; gene expression;

    Abstract : Huntington's disease (HD) is a devastating, inherited neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. Peripheral symptoms, such as skeletal muscle wasting, progressive weight loss, altered body composition and endocrine disturbances exist alongside neurodegeneration. READ MORE

  2. 2. β-cell dysfunction in Huntington's disease

    University dissertation from Department of Clinical Sciences, Lund University

    Author : Karl Bacos; Lunds universitet.; Lund University.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metabolism; secretion; Insulin; trafficking; R6 2 mouse; granule; exocytosis; neurodegeneration; huntingtin;

    Abstract : Huntington's disease (HD), a fatal neurodegenerative disorder, is associated with an increased risk of diabetes mellitus. The reason for this is unknown, but considering the functional similarities of neurons and the insulin secreting pancreatic β-cell, pathological mechanisms may be shared by both cell types and account for neuronal as well as endocrine dysfunction. READ MORE

  3. 3. Effects of dopamine and excitotoxicity in experimental models of Huntington's disease

    University dissertation from Åsa Petersén, WNC, BMC A10, 221 84 Lund, Sweden

    Author : Åsa Petersén; Lunds universitet.; Lund University.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; excitotoxicity; dopamine; Huntington s disease; striatum; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Abstract : Popular Abstract in Swedish Denna avhandling handlar om en ärftlig hjärnsjukdom som heter Huntingtons sjukdom, eller danssjuka. Sjukdomen leder till personlighetsförändringar, ofrivilliga rörelser (som ser ut som om personen dansar) och demens. READ MORE

  4. 4. Neuronal Cell Death and Restoration in the Basal Ganglia: Implications for Huntington's and Parkinson's diseases

    University dissertation from Wallenberg Neuroscience Center, BMC, Lund University

    Author : Oskar Hansson; Lunds universitet.; Lund University.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; basal ganglia; Parkinson s disease; Huntington s disease; neural transplantation; restoration; NMDA receptor; excitotoxicity; calcium; caspase; neuronal cell death; apoptosis; transgenic mouse; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Abstract : Popular Abstract in Swedish Basala ganglierna ligger under hjärnbarken i hjärnan och består av grupper av nervceller som är förbundna med varandra och med hjärnbarken. Till dessa grupper av nervceller hör striatum, globus pallidus, subthalamicus-kärnan och substantia nigra. READ MORE

  5. 5. Beyond the basal ganglia

    University dissertation from Institutionen för Experimentell Medicinsk Vetenskap, Lunds Universitet

    Author : Jorien m van der Burg; Lunds universitet.; Lund University.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hypothalamus; gastro-intestinal tract; Huntington s disease; metabolism; weight loss;

    Abstract : Huntington’s disease (HD) is a fatal, hereditary disorder caused by a mutation in the gene encoding the protein huntingtin. Although mutant huntingtin is ubiquitously expressed throughout the body, HD research has mainly focused on the role of the basal ganglia. READ MORE