Search for dissertations about: "RAC1"

Showing result 1 - 5 of 48 swedish dissertations containing the word RAC1.

  2. 1. Rac1 signaling regulates platelet-dependent inflammation abdominal sepsis

    Author : Rundk Hwaiz; Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; abdominal sepsis; Rac1; platelet; neutrophil; chemokine; inflammation;

    Abstract : Sepsis is a systemic inflammatory response syndrome to a localized or systemic infection that leads to the over production of proinflammatory cytokines and the ultimate failure of multiple organ systems. However, little is known about the potential role of Rac1 in controlling sepsis-induced intracellular signaling pathways. READ MORE

  4. 2. Rho-GTPases in Morphogenesis and Differentiation of the Developing Pancreas

    Author : Thomas Greiner; Stamcellscentrum (SCC); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; insulin; diabetes; beta cell; cell adhesion; migration; delamination; morphogenesis; tubulogenesis; pancreas; Cdc42; Rho-GTPase; Rac1;

    Abstract : Branched tubular networks constitute the basic structure of many organs to increase surface area and to transport fluids and gases. Glandular organs such as the pancreas arise from multilayered epithelium, which undergoes de novo lumen formation and extensive remodeling and branching. READ MORE

  5. 3. Defining the importance of protein geranylgeranylation in innate immunity

    Author : Murali K Akula; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CAAX proteins; GGTase-I; RAC1; statins;

    Abstract : RHO family proteins and other intracellular proteins are prenylated with a 20-carbon lipid—a product of the cholesterol synthesis pathway—by protein geranylgeranyltransferase type I (GGTase-I). Prenylation is widely believed to target proteins to membranes where they encounter effector molecules that stimulate GTP-binding and activation. READ MORE

  6. 4. Prognostic Biomarkers and Target Proteins for Treatment of High-grade Gliomas

    Author : Linda Sooman; Simon Ekman; Johan Lennartsson; Joachim Gullbo; Michael Bergqvist; Erik Blomquist; Stefan Bergström; Beatrice Melin; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; High-grade glioma; prognostic biomarkers; combination chemotherapy; DNA methylation; FGF2; p38 MAPK; PTPN6; camptothecin; imatinib; vandetanib; EGFR; RAC1; Notch; Medical Science; Medicinsk vetenskap; Oncology; Onkologi;

    Abstract : The survival for high-grade glioma patients is poor and the treatment may cause severe side effects. A common obstacle in the treatment is chemoresistance. To improve the quality of life and prolong survival for these patients prognostic biomarkers and new approaches for chemotherapy are needed. READ MORE

  7. 5. Cdc42 and Rac1 in Pancreatic Tubulogenesis and Islet Formation

    Author : Gokul Kesavan; Stamcellscentrum (SCC); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Tubes form the basic structure of several organs like lungs, kidneys, glandular organs like the pancreas, mammary and salivary glands. Tube formation involves a series of dynamic and interdependent cellular processes, including cytoskeletal reorganization, assembly of intercellular junctional complexes, and cell polarization. READ MORE