Search for dissertations about: "RAGE"

Showing result 6 - 10 of 32 swedish dissertations containing the word RAGE.

  2. 6. Diabetes and peripheral arterial disease

    Author : Jonas Malmstedt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: Diabetes mellitus increases the risk for peripheral arterial disease (PAD) early in life and the disease is likely to progress to advanced stages. Mechanisms responsible for premature PAD in diabetes are partly unknown. READ MORE

  4. 7. The inflammatory and immunogenic properties of the receptor for advanced glycation end products and its ligand, high mobility group box chromosomal protein 1

    Author : Rille Pullerits; Göteborgs universitet; []
    Keywords : HMGB1; sRAGE; rheumatoid arthritis; inflammation; cytokines;

    Abstract : Rheumatoid arthritis (RA) is a chronic systemic inflammatory joint disease, the pathogenesis of which is complex, involving a wide range of molecules. High mobility group box chromosomal protein 1 (HMGB1) is a nuclear protein recently recognised as a pro-inflammatory cytokine which levels are increased in RA patients. READ MORE

  5. 8. Characterisation of HMGB1 in inflammation

    Author : Therese Östberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : High mobility group box chromosomal protein 1 (HMGB1) was discovered over three decades ago as a nuclear protein which is present in all mammalian nucleated cells. Subsequent studies have revealed additional properties of HMGB1 besides its originally described nuclear functions. READ MORE

  6. 9. On the importance of inflammation for personality traits and psychiatric morbidity

    Author : Petra Suchankova; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; inflammation; C-reactive protein; complement factor H; S100B; receptor for advanced glycation end products; polymorphism; gene expression; personality traits; suicidal behaviour; schizophrenia; depression; Flinders sensitive line;

    Abstract : Background: Pro-inflammatory mediators have been implicated in processes that could be both beneficial and toxic to cells in the brain. On the one hand balanced levels of these mediators favour e.g. READ MORE

  7. 10. Preterm and term cervical ripening : studies on CRH, HMGB1, toll-like receptors, cytokines and matrix metalloproteinases

    Author : Aurelija Dubicke; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cervical fibroblasts; cervical ripening; cervix; chemokines; cytokines; CRH; HMGB1; interleukin; labor; preterm; preterm labor; matrix metalloproteinases; pregnancy; PPROM; Tolllike receptors;

    Abstract : Objective: Preterm birth (PTB) is the leading cause of neonatal mortality and morbidity. Despite the existing treatment, the frequency of PTB has not changed in the past thirty years. Incomplete understanding of the biological and pathophysiological mechanisms underlying preterm delivery is the major obstacle to preventing PTB. READ MORE