Search for dissertations about: "RANK KO"

Found 2 swedish dissertations containing the words RANK KO.

  2. 1. Development of Novel Models for Studying Osteoclasts

    Author : Christian Thudium; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Osteoclast; Osteopetrosis; Osteoporosis; Bone; Hematopoiesis; Gene Therapy; Mouse Models; oc oc; RANK KO;

    Abstract : This thesis focuses on developing and characterizing novel models for studying osteoclasts with an emphasis on how mutations abolishing osteoclastic acidification affect osteoclast signaling and bone remodeling, as well as how to treat patients bearing these rare mutations. Bone remodeling is under normal circumstances a tightly balanced process where resorption of bone by osteoclasts is followed by adequate amounts of bone formation by osteoblasts. READ MORE

  4. 2. The role of mechanical loading, sex and TRAP/ACP5 on bone properties

    Author : Suchita Desai; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : A well-balanced bone structure involves a balanced role of the osteoclasts, osteoblasts, and osteocytes. The balance is maintained by different internal and external factors like calcium demands, the immune system and its cytokines, or mechanical loading. READ MORE