Search for dissertations about: "RANKL"

Showing result 1 - 5 of 34 swedish dissertations containing the word RANKL.

  1. 1. On the Role of Osteoprotegerin/RANK/RANKL System in the Interaction between Prostate Cancer and Bone

    Author : Hendrik Penno; Östen Ljunggren; Olof Nilsson; Andreas Kindmark; Pernilla Lundberg; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metastases; bone; prostate cancer; osteoprotegerin; RANKL; osteoporosis; genetics; polymorphisms; Orthopaedics; Ortopedi;

    Abstract : Metastases to bone are observed in around 80% of prostate cancer patients and represent the most critical complication of advanced prostate cancer. Unlike other solid tumors that are associated with osteolytic bone metastases, prostate cancer bone metastases stimulate osteoblastic activity with sclerosis in the bone lesions as a consequence. READ MORE

  2. 2. Early rheumatoid arthritis : biomarkers and hormonal factors in relation to disease progression

    Author : Antonia Boman; Solbritt Rantapää-Dahlqvist; Ewa Berglin; Gerd-Marie Alenius; Mikael Brink; Heidi Kokkonen; Inger Gjertsson; Umeå universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Early rheumatoid arthritis; biomarker; ACPA; RANKL; disease activity; radiological destruction; cardiovascular events; hormonal factors; reumatologi; rheumatology;

    Abstract : Rheumatoid arthritis (RA) is a chronic inflammatory joint disease, affecting approximately 0.5 to 1% of the adult population. Although the aetiology is not fully known, a complex interaction between genetic, environmental and stochastic factors is thought to trigger the pathogenic mechanisms. READ MORE

  3. 3. Kinins : important regulators in inflammation induced bone resorption

    Author : Anna Bernhold Brechter; Ulf Lerner; Hans-Erik Claesson; Umeå universitet; []
    Keywords : Bone resorption; Osteoblasts; Kinins; B1 and B2 receptors; IL-1β; TNF-α; Prostaglandin; COX-2; RANKL; Transcription factors; IL-4; IL-13; Medical Cell Biology; medicinsk cellbiologi;

    Abstract : Inflammatory processes in, or in close vicinity of, the skeleton often lead to loss of bone tissue. Different cytokines have been shown to be involved as stimulators of inflammatory induced osteoclastic bone resorption. READ MORE

  4. 4. Studies of molecular mechanisms of action of TNF antagonists in rheumatoid arthritis

    Author : Anca Irinel Catrina; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Rheumatoid arthritis; TNF antagonists; cytokines; macrophages; matrix metalloproteinases; osteoprotegerin; RANKL; apoptosis;

    Abstract : Rheumatoid Arthritis (RA) is a common chronic inflammatory disease characterized by progressive bone destruction that leads to joint deformity and physical disability. Even though several therapeutic drugs are available, none have emerged as an ideal RA treatment that delays joint destruction and halts disease progression. READ MORE

  5. 5. Immunopathogenic studies on inflammation and bone destruction in rheumatoid arthritis

    Author : Shankar Kumar Revu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Rheumatoid arthritis (RA) is a chronic systemic joint disease characterized by synovial inflammation, leading to destruction of cartilage and bone. Local recruitment of immune cells and defective apoptosis results in chronic inflammation with increased synovial citrullination and local hypoxia. READ MORE