Search for dissertations about: "RANKL"

Showing result 11 - 15 of 36 swedish dissertations containing the word RANKL.

  2. 11. Cellular and molecular responses of periodontal connective tissue cells to Actinobacillus actinomycetemcomitans cytolethal distending toxin

    Author : Georgios N. Belibasakis; Sotirios Kalfas; Ulf H. Lerner; Anders Johansson; Veli-Jukka Uitto; Umeå universitet; []
    Keywords : Medical sciences; Actinobacillus actinomycetemcomitans; cytolethal distending toxin; periodontal connective tissue cells; localized aggressive periodontitis; growth arrest; bone resorption; receptor activator of NF-κB ligand; osteoprotegerin; pro-inflammatory cytokines; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; odontologi; Odontology;

    Abstract : Actinobacillus actinomycetemcomitans is present in elevated proportions and numbers in dental bacterial biofilms of patients with localized aggressive periodontitis. This variant of periodontal disease, occurring in adolescents and young adults, is characterized by rapid and severe destruction of the connective tissues and bone supporting the teeth, eventually culminating in tooth loss. READ MORE

  4. 12. The calcitonin gene family of peptides : receptor expression and effects on bone cells

    Author : Susanne Granholm; Ulf Lerner; Pernilla Lundberg; Göran Andersson; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; CT family of peptides; osteoclast differentiation; bone resorption; CTR; CRLR; RAMPs; Cell biology; Cellbiologi;

    Abstract : The calcitonin gene family of peptides consists of calcitonin (CT), two calcitonin gene related peptides (α-CGRP, β-CGRP), adrenomedullin (ADM), amylin (AMY), three calcitonin receptor activating peptides (CRSP1-3) and intermedin/adrenomedullin2 (IMD). These peptides bind to one of two G protein -coupled receptors, the calcitonin receptor (CTR) or the calcitonin receptor-like receptor (CRLR). READ MORE

  5. 13. Periodontal medicine : oral inflammatory conditions with special emphasis on immunological aspects

    Author : Jeneen Panezai; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Systemic effects of periodontal disease have been a subject of interest for the past century, with intense focus converging since the past decade. Both rheumatoid arthritis (RA) and periodontal disease (PD) are immuno-inflammatory diseases with osteolysis as its hallmark feature. Activated T cells are known to modulate osteoclastogenesis. READ MORE

  6. 14. Post-translational and therapy-induced modifications in rheumatoid arthritis

    Author : Dimitrios Makrygiannakis; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial proliferation and excessive mononuclear infiltration leading to destruction of bone and cartilage, with subsequent joint deformities and physical disability. Even though RA etiology is still unknown, autoantibody driven pathogenic mechanisms are considered to be important, with strong evidence for the pathogenic potentials of antibodies directed against citrullinated antigens. READ MORE

  7. 15. Functional aspects of prothrombin in bone

    Author : Erik Karlström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Prothrombin (PT) is the inactive zymogen to the serine protease alpha-thrombin which in the coagulation cascade is responsible for clot formation through converting fibrinogen to fibrin. PT has been shown to be present in calcified bone matrix, and alpha-thrombin has been implicated in various bone resorbing disorders of inflammatory origin, such as rheumatoid arthritis and periodontitis. READ MORE