Search for dissertations about: "RAS cAMP pathway"

Found 5 swedish dissertations containing the words RAS cAMP pathway.

  2. 1. Mating type switching and transcriptional silencing in Kluyveromyces lactis

    Author : Emad Barsoum; Åström Stefan; Laura Rusche; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mating type switch; transcriptional silencing; alpha3; transposase; Ume6; Mts1; Ras; cAMP; K. lactis; Developmental biology; Utvecklingsbiologi; utvecklingsbiologi; Developmental Biology;

    Abstract : To explore the similarities and differences of regulatory circuits among budding yeasts, we characterized the role of unscheduled meiotic gene expression 6 (UME6) and a novel mating type switching pathway in Kluyveromyces lactis. We found that Ume6 was required for transcriptional silencing of the cryptic mating-type loci HMLα and HMRa. READ MORE

  4. 2. Regulation and mechanism of mating-type switching in Kluyveromyces lactis

    Author : Naghmeh Rajaei; Stefan Åström; Kenneth Wolfe; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; yeast; mating-type switching; DSB; gene conversion; transposable elements; RAS cAMP pathway; nutrient limitation; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Transposable elements (TEs) have had immense impact on the structure, function and evolution of eukaryotic genomes. The work in this thesis identified Kat1, a novel domesticated DNA transposase of the hAT family in the yeast Kluyveromyces lactis. Kat1 triggers a genome rearrangement that results in a switch of mating type from MATa to MATα. READ MORE

  5. 3. Functional studies in yeast of cyclin C and the RNA polymerase II Mediator complex

    Author : Darius Balciunas; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Cyclin C; RNA polymerase II; Mediator; glucose repression; RAS cAMP pathway; Saccharomyces cerevisiae; Biokemi; Biochemistry; Biokemi; Medical Biochemistry; medicinsk biokemi;

    Abstract : Cyclin C belongs to a group of cyclins that are not cell cycle-regulated. It was first cloned from Drosophila and rat, but its role was not understood until the yeast cyclin C homologue Srb 11 was identified in several genetic screens for transcriptional repressors and subsequently was shown to be associated with the RNA polymerase II Mediator complex. READ MORE

  6. 4. Adenosine receptor signaling and the activation of mitogen-activated protein kinases

    Author : Gunnar Schulte; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The nucleoside adenosine is present in all cells and body fluids of all living organisms; its production, both intracellularly and extracellularly, is tightly coupled to energy consumption resulting in increasing extracellular adenosine levels with increased energy consumption. Adenosine is metabolized by adenosine deaminase and adenosine kinase. READ MORE

  7. 5. Metabolic regulation and anticancer drug resistance in the yeast Saccharomyces cerevisiae

    Author : Mattias Carlsson; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Cancer is a malignant neoplastic tissue. The pyrimidine analogue 5-fluorouracil is an anticancer drug used against several types of cancer. It owes its specificity against neoplasms due to the higher rate of nutrient uptake, RNA and DNA synthesis, and in particular the higher rate of nucleobase scavenging and salvage of neoplastic cells. READ MORE