Search for dissertations about: "RBC model"

Showing result 1 - 5 of 19 swedish dissertations containing the words RBC model.

  2. 1. Model-based quantitative assessment of skin microcirculatory blood flow and oxygen saturation

    Author : Hanna Jonasson; Tomas Strömberg; Bruce Tromberg; Linköpings universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

    Abstract : The microcirculation, involving the smallest vessels in the body, is where the oxygen transport to all tissue occurs. Evaluating microcirculatory parameters is, therefore, important and involves the quantification of oxygen content of red blood cells (RBCs), the amount of RBCs and their speed. READ MORE

  4. 2. Heparan sulfate dependent sequestration during Plasmodium falciparum malaria

    Author : Anna Vogt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Severe malaria; Plasmodium falciparum; sequestration; endothelial adhesion; erythrocyte rosetting; PfEMP1; DBL1alpha; heparan sulfate; heparin; animal model.;

    Abstract : Plasmodium falciparum infected erythrocytes are able to bind to the microvascular endothelium (cytoadherence), and to uninfected erythrocytes (rosetting) that lead to excessive sequestration of the parasites. This causes obstruction of the deep microvasculature by P. READ MORE

  5. 3. Erythrocyte amino acids in health and renal failure and their association to the IGF-I/IGFBP-1 axis

    Author : José Carolino Divino Filho; Karolinska Institutet; Karolinska Institutet; []
    Keywords : amino acid; ASP DNA; catabolism dialysis; erythrocytes; glutamate; glutamine; health; human; IGF-I; IGFBP-1; muscle; plasmaprotein intake; rat; renal failure; uraemia;

    Abstract : Abnormalities in amino acids (AA) metabolism in uraemia have mainly been reported to occur in plasma and muscle. No investigation has been undertaken to evaluate the AA levels in plasma, muscle and red blood cells (RBC) simultaneously, although the RBC pool of free AA constitutes a large proportion of the free AA in blood, and RBC are involved in the interorgan transport of AA. READ MORE

  6. 4. Quantitative Laser Doppler Flowmetry

    Author : Ingemar Fredriksson; Tomas Strömberg; Marcus Larsson; Weindelt Stenbergen; Linköpings universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Medical engineering; Medicinsk teknik;

    Abstract : Laser Doppler flowmetry (LDF) is virtually the only non-invasive technique, except for other laser speckle based techniques, that enables estimation of the microcirculatory blood flow. The technique was introduced into the field of biomedical engineering in the 1970s, and a rapid evolvement followed during the 1980s with fiber based systems and improved signal analysis. READ MORE

  7. 5. Safety and Efficacy Modelling in Anti-Diabetic Drug Development

    Author : Bengt Hamrén; Mats O Karlsson; Eric Snoeck; Uppsala universitet; []
    Keywords : Pharmaceutical biosciences; pharmacokinetic; pharmacodynamic; mechanism-based; modelling; type 2 diabetes mellitus; tesaglitazar; PPAR; drug development; NONMEM; Farmaceutisk biovetenskap;

    Abstract : A central aim in drug development is to ensure that the new drug is efficacious and safe in the intended patient population. Mathematical models describing the pharmacokinetic-pharmacodynamic (PK-PD) properties of a drug are valuable to increase the knowledge about drug effects and disease and can be used to inform decisions. READ MORE