Search for dissertations about: "RBP"
Showing result 11 - 15 of 22 swedish dissertations containing the word RBP.
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11. Sarcoma ecosystems : spatial characterization and prognostic significance
Abstract : Sarcoma is a highly heterogeneous disease with complex biological activities and unique tumor microenvironments (TME) in distinct subtypes. The limited treatment options and inadequate responses to current therapies necessitate a deeper understanding of sarcoma biology and personalized treatment strategies. READ MORE
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12. Notch signalling in carcinogenesis : With special emphasis on T-cell lymphoma and colorectal cancer
Abstract : The Notch signalling pathway is an evolutionary conserved pathway, named after the Notch receptors, Notch1-4 in mammals, which upon cell-cell contact and ligand binding releases the intracellular domain (NICD). NICD translocates into the nucleus where it binds the transcriptional repressor RBP-Jk, which together with co-activators belonging to the Mastermind-like family of proteins form a transcriptional activation complex. READ MORE
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13. Vitamins, fatty acids, physical activity and peak bone mass
Abstract : Osteoporosis is a disease characterized by low bone mineral density, deteriorated bone microstructure and increased fracture risk. About 50% of all women and 25% of all men will have an osteoporotic fracture. Given that there is no effective cure in established osteoporosis, prevention is of high importance. READ MORE
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14. Molecular aspects of retinol uptake and activation
Abstract : Retinoids (vitamin A derivatives) are essential for a wide variety of physiological processes, including embryonic development, growth, vision, reproduction, and maintenance of various epithelia and the immune system. 11-Cis-retinal serves as the chromophore of the visual pigments in the retina, whereas the hormonal retinoids, all-trans and 9-cis retinoic acid (RA), regulate the non-visual functions via activation of nuclear retinoid receptors (RARs and RXRs). READ MORE
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15. Structural Studies of Binding Proteins: Investigations of Flexibility, Specificity and Stability
Abstract : Binding proteins are present both in gram-negative and gram-positive bacteria. They are the recognition components of the ABC transport systems that transport different nutrients into the cell, and are in some cases also involved in chemotaxis. READ MORE