Search for dissertations about: "RCR"

Showing result 1 - 5 of 7 swedish dissertations containing the word RCR.

  2. 1. Padlock Probes and Rolling Circle Amplification : New Possibilities for Sensitive Gene Detection

    Author : Maritha Mendel-Hartvig; Pål Nyrén; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Padlock probes; RCR; in situ hybridization; branched DNA; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

    Abstract : A series of novel methods for detection of known sequence variants in DNA, in particular single nucleotide polymorphism, using padlock probes and rolling circle replication are presented. DNA probes that can be circularized – padlock probes – are ideal for rolling circle replication. READ MORE

  4. 2. Radiobiological end-points for the theoretical evaluation of the effectiveness of carbon ions and photons in treating tumours with dynamic hypoxia

    Author : Antonovic Laura; Iuliana Toma-Dasu; Tatsuaki Kanai; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; OER; hypoxia; LOC; RCR; hypofractionation; SBRT; carbon ion; fractionation; TCP; SF; RCE; RBE; Medical Radiation Physics; medicinsk strålningsfysik;

    Abstract : Tumours are characterised by unorganised vasculature, which often results in hypoxic regions. Hypoxia is a common cause for photon radiotherapy (RT) treatment failure, as hypoxic cells require up to 2-3 times higher doses compared to well-oxygenated cells for the same effect in terms of cell kill. READ MORE

  5. 3. From cell survival to dose response : modeling biological effects in radiation therapy

    Author : Minna Wedenberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Radiobiological models;

    Abstract : The main goal in curative radiation therapy is to eradicate the tumor while minimizing radiation-induced damage to normal tissue. Ions, including protons and carbon ions, are increasingly being used for cancer treatment. READ MORE

  6. 4. Analysis and characterization of chemo- and radiation therapy sensitizing strategies in tumours with focus on effects of phenothiazines on DNA damage response signalling

    Author : Katarzyna Zielinska-Chomej; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cancer is, despite rapid progress in development of new targeted therapies, still mainly treated with surgery, chemotherapy and/or radiation therapy. The last two mentioned conventional therapies often meet general obstacles such as normal cell toxicity and tumour cell resistance. READ MORE

  7. 5. Aspects of renal blood flow and oxygenation in acute kidney injury during severe infections

    Author : Tomas Luther; Robert Frithiof; Michael Hultström; Per Liss; Rafael Kawati; Anders Åneman; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute kidney injury; renal blood flow; renal oxygenation; COVID-19; fluids; mitochondria; sepsis; acute respiratory distress syndrome; magnetic resonance imaging; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care;

    Abstract : Acute kidney injury (AKI) is a common complication in patients treated in the intensive care unit (ICU). Severe infections/sepsis is the most common aetiology, and about half of patients treated in the ICU due to sepsis are affected. Although AKI often resolves over time, the development of AKI decreases the chances of surviving. READ MORE