Search for dissertations about: "RETINOIC ACID, macrophages"

Showing result 1 - 5 of 8 swedish dissertations containing the words RETINOIC ACID, macrophages.

  2. 1. CYP26B1 as regulator of retinoic acid in vascular cells and atherosclerotic lesions

    Author : Ali Ateia Elmabsout; Allan Sirsjö; Karin Fransén; Helen Håkansson; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CYP26B1; alternative splice; vascular cells; atherosclerosis; alltrans-retinoic acid; gene polymorphism; inflammation; statins; Medicine; Medicin;

    Abstract : Cardiovascular disease (CVD), currently the most common cause of morbidity and mortality worldwide, is caused mainly by atherosclerosis. Atherosclerosis is a chronic multifocal, immunoinflammatory, fibroproliferative disease of medium and large arteries. READ MORE

  4. 2. Phenotype and function of intestinal CD103+ dendritic cells

    Author : Elin Jaensson Gyllenbäck; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD103; dendritic cell; CX3CR1; small intestine; MLN; CCR9; Vitamin A; retinoic acid;

    Abstract : Mucosal tissues such as the intestine present an enormous surface area to the outside environment and are continually exposed to foreign antigens in food and microflora. Thus, the intestinal mucosa must must remain tolerant to these innocuous antigens while at same time be able to mount effective immune responses to pathogens. READ MORE

  5. 3. Cellular immunity and inflammation in atherosclerosis

    Author : Dirk Marcus Wuttge; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Atherosclerosis; T cell; oxLDL; malondialdehyde; hapten; posttranslational; interleukin-] 5; retinoic acid receptor; inflammation;

    Abstract : Atherosclerosis, the major cause of death and disability in western countries, is nowadays recognized as an inflammatory disease. Low density lipoprotein (LDL), the major carrier of cholesterol in plasma, is trapped in the subendothelial space, where compounds inside of LDL are chemically modified through lipid peroxidation. READ MORE

  6. 4. Identification of natural activators of the nuclear receptor peroxisome proliferator-activated receptor : relevance to the pathogenesis of atherosclerosis

    Author : Jane Wigren; Ernst Oliw; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Polyunsaturated fatty acids induce peroxisome proliferation. This phenomenon is mediated by the ligand-dependent transcription factor peroxisome proliferator-activated receptor (PPAR). This thesis is an investigation on the role of eicosanoids and oxidized products of linoleic acid for the activation of PPARs. READ MORE

  7. 5. Impact of genetic and environmental factors in intestinal inflammation

    Author : Oscar Eduardo Diaz Perez; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The gastrointestinal tract, is continuously exposed to a wide variety of stimuli, including dietary-derived metabolites, environmental compounds and the microbiota. Since these antigens can be beneficial or detrimental for the organism, proper sensing of the luminal content is essential for orchestrating both pro-inflammatory and tolerogenic immune responses on demand and therefore, ensure the establishment of intestinal homeostasis. READ MORE