Search for dissertations about: "RNA amplification"

Showing result 11 - 15 of 65 swedish dissertations containing the words RNA amplification.

  2. 11. Sample-to-answer paper-based nucleic acid amplification tests

    Author : Georgios Chondrogiannis; Mahiar Hamedi; Jeff Mold; Keith Pardee; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Fiber- och polymervetenskap; Fibre and Polymer Science;

    Abstract : Nucleic Acid Amplification Tests (NAATs) with PCR technology to amplify DNA, are the golden standard for infectious disease diagnostics, but they require benchtop instruments and trained users to be performed. For this reason, we all had to send PCR test to centralized laboratories during the Covid-19 pandemic. READ MORE

  4. 12. The RNA exosome and the maintenance of genome integrity

    Author : Judit Domingo Prim; Neus Visa; Andrés Aguilera; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; EXOSC10; RRP6; DNA damage; diRNA; DDRNA; DNA end resection; homologous recombination; molekylär biovetenskap; Molecular Bioscience;

    Abstract : The RNA exosome is a ribonucleolytic complex that acts on different RNA substrates and plays important roles in RNA metabolism. In recent years, the synthesis and the processing of RNA have been directly linked to the integrity of the genome. READ MORE

  5. 13. Parallel target selection by trinucleotide threading

    Author : Pawel Zajac; Joakim Lundeberg; Afshin Ahmadian; Mats Nilsson; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; trinucleotide threading; multiplex amplification; expression profiling; microarray; generic tag; short tandem repeat; microsatellite; electrophoresis; single nucleotide polymorphism; allelotyping; 454; Pyrosequencing; Genetic engineering including functional genomics; Genteknik inkl. funktionsgenomik;

    Abstract : DNA is the code for all life. Via intermediary RNA the information encoded by the genome is relayed to proteins executing the various functions in a cell. Together, this repertoire of inherently linked biological macromolecules determines all characteristics and features of a cell. READ MORE

  6. 14. Counting molecules in cell-free DNA and single cells RNA

    Author : Kasper Karlsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : UMI;

    Abstract : The field of Molecular Biology got started in earnest with the discovery of the molecular structure of DNA. This lead to a surge of interest into the relationships between DNA, RNA and proteins, and to the development of fundamental tools for manipulating those substances, such as cutting, ligating, amplifying, visualizing and size-selecting DNA. READ MORE

  7. 15. Defining Regulators of Human Hematopoietic Stem Cells

    Author : Christine Karlsson; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; High-throughput screening; Expansion; Hematopoietic stem cell; Cord blood; RNA interference; extrinsic Signaling molecules;

    Abstract : Bone marrow transplantation (BMT) is a conceptual and elegant example of stem cell therapy, rendered possible by the dual capacity of hematopoietic stem cells (HSCs) to self-renew and differentiate. These defining features ultimately ensure the production of all blood cell lineages and simultaneous maintenance of the stem cell pool, thereby maintaining lifelong homeostasis. READ MORE