Search for dissertations about: "RNA expression"

Showing result 21 - 25 of 921 swedish dissertations containing the words RNA expression.

  2. 21. Epigenetic Regulation by Noncoding RNA

    Author : Tanmoy Mondal; Chandrasekhar Kanduri; Jérôme Cavaillé; Uppsala universitet; []
    Keywords : Genomic Imprinting; Noncoding RNA; Epigenetics; DNA methylation; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Abstract : High throughput transcriptomic analyses have realized us with the fact that eukaryotic genome encodes thousands of noncoding RNAs (ncRNAs) with unknown function. In my thesis, I sought to address epigenetic regulation of transcription by ncRNA using the Kcnq1 imprinted cluster as a model system. READ MORE

  4. 22. Atypical Solute Carriers : Identification, evolutionary conservation, structure and histology of novel membrane-bound transporters

    Author : Emelie Perland; Robert Fredriksson; Helgi Schiöth; Åsa Mackenzie; Sonchita Bagchi; Carsten Uhd Nielsen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Major facilitator superfamily; solute carrier; transporter; protein expression; mRNA expression; phylogenetic clustering; orthologues; co-expression; subcellular location; nutrition.; Neuroscience; Neurovetenskap;

    Abstract : Solute carriers (SLCs) constitute the largest family of membrane-bound transporter proteins in humans, and they convey transport of nutrients, ions, drugs and waste over cellular membranes via facilitative diffusion, co-transport or exchange. Several SLCs are associated with diseases and their location in membranes and specific substrate transport makes them excellent as drug targets. READ MORE

  5. 23. Hidden patterns that matter : statistical methods for analysis of DNA and RNA data

    Author : Therese Kellgren; Patrik Rydén; Sara Sjöstedt de Luna; Rebecka Jörnsten; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Genome; Next-generation sequence; statistics; microarrays; bacteria; antibiotic resistance; inherited diseases; Co-expression networks; centralization within subgroups;

    Abstract : Understanding how the genetic variations can affect characteristics and function of organisms can help researchers and medical doctors to detect genetic alterations that cause disease and reveal genes that causes antibiotic resistance. The opportunities and progress associated with such data come however with challenges related to statistical analysis. READ MORE

  6. 24. Exploring genetic heterogeneity in cancer using high-throughput DNA and RNA sequencing

    Author : Erik Fasterius; Cristina Al-Khalili Szigyarto; Mathias Uhlén; Peter-Bram ’t Hoen; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Biotechnology; bioinformatics; RNA-seq; WGS; WES; systems biology; variant analysis; single nucleotide variant; gene expression; machine learning; clustering; open source; R; bioconductor; Python; Bioteknologi; Biotechnology;

    Abstract : High-throughput sequencing (HTS) technology has revolutionised the biomedical sciences, where it is used to analyse the genetic makeup and gene expression patterns of both primary patient tissue samples and models cultivated in vitro. This makes it especially useful for research on cancer, a disease that is characterised by its deadliness and genetic heterogeneity. READ MORE

  7. 25. Integration of RNA and protein expression profiles to study human cells

    Author : Frida Danielsson; Emma Lundberg; Mikael Huss; Mathias Uhlén; Christine Vogel; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; RNA-seq; Transcriptomics; Proteomics; Malignant transformation; Cancer; Functional enrichment; Bioteknologi; Biotechnology; Medical Technology; Medicinsk teknologi;

    Abstract : Cellular life is highly complex. In order to expand our understanding of the workings of human cells, in particular in the context of health and disease, detailed knowledge about the underlying molecular systems is needed. READ MORE