Search for dissertations about: "RNA interference"

Showing result 1 - 5 of 78 swedish dissertations containing the words RNA interference.

  1. 1. Identification of intrinsic regulators in normal and malignant human hematopoiesis. An RNA-interference approach

    University dissertation from Lund University: Faculty of Medicine

    Author : Roman Galeev; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2018]
    Keywords : hematopoietic stem cell; RNA interference; Acute myeloid leukemia; myelodysplastic syndrome; genetic screens; next generation sequencing; genetic regulators;

    Abstract : Bildandet av blodceller, hematopoesen, utgår från ett litet antal av de så kallade hematopoetiska stamceller som sitter i vår benmärg. Dessa celler har förmågan att ge upphov till alla mogna blodcellstyper av de tre hematopoetiska linjerna, samtidigt som de genom celldelning bibehåller sin egna mängd. READ MORE

  2. 2. A-to-I RNA editing : Function and consequences during brain development

    University dissertation from Stockholm : Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University

    Author : Ylva Ekdahl; Stockholms universitet.; [2013]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; RNA editing; miRNAs; Brain development; molekylärbiologi; Molecular Biology;

    Abstract : The aim of my thesis has been to study how A-to-I RNA editing of miRNAs is regulated during brain development and the biological function of these editing events.Using high throughput RNA sequencing, we performed an unbiased search for edited, mature miRNAs in total mouse brain tissue from three developmental stages. READ MORE

  3. 3. Extracellular Vesicles and RNA interference in tumors

    University dissertation from Stockholm : Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University

    Author : Taral R Lunavat; Göteborgs universitet.; Gothenburg University.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melanoma; Therapeutics; Exosome-mimetic nanovesicles; Apoptotic bodies; Microvesicles; Exosomes;

    Abstract : Extracellular vesicles (EVs) including apoptotic bodies (ABs), microvesicles (MVs), exosomes (EXOs) and cell derived artificial nanovesicles (NVs) are important mediators of cell-to-cell communication, in part by transferring bioactive molecules such as DNA, mRNA, miRNA, siRNA, proteins, and lipids. These EVs are released by many cell types, including melanoma cells, and are found in many body fluids. READ MORE

  4. 4. Construction of Adenovirus Vectors for Studies of Protein Function and RNA Interference

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Saideh Berenjian; Uppsala universitet.; [2006]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Microbiology; Adenovirus; viral vectors; VA RNAI II; RNAi; Tet-ON OFF; RNA splicing; Mikrobiologi; NATURAL SCIENCES Biology Organism biology Microbiology; NATURVETENSKAP Biologi Organismbiologi Mikrobiologi;

    Abstract : During an adenovirus infection the accumulation of alternatively spliced mRNAs is subjected to a tight temporal regulation. The IIIa protein is a structural protein expressed exclusively late after infection. READ MORE

  5. 5. Making Sense of Antisense

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Johan Reimegård; Uppsala universitet.; [2010]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; sRNA; miRNA; RNA; target prediction; SOLiD siRNA; E.coli; D.discoideum; NATURAL SCIENCES Biology; NATURVETENSKAP Biologi; Bioinformatik; Bioinformatics; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Abstract : RNA is a highly versatile molecule with functions that span from being a messenger in the transfer from DNA to protein, a catalytic molecule important for key processes in the cell to a regulator of gene expression. The post-genomic era and the use of new techniques to sequence RNAs have dramatically increased the number of regulatory RNAs during the last decade. READ MORE