Search for dissertations about: "RNA virus"

Showing result 6 - 10 of 283 swedish dissertations containing the words RNA virus.

  2. 6. iLocks: a novel tool for RNA assays with improved specificity

    Author : Tomasz Krzywkowski; Mats Nilsson; Gunnar von Heijne; Weng-Onn Lui; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; RNA; miRNA; non-coding RNA; padlock probes; rolling circle amplification; invader; single cell; in situ; adenovirus; virology; diagnostics; Biochemistry; biokemi;

    Abstract : The Central Dogma of molecular biology describes a framework for how genetic information is transferred in cells, placing RNA as a messenger between DNA and translated proteins. During the last years, interest in RNA research has grown tremendously due to the increasing understanding and recognition of the importance of RNA in regulation of gene expression, biochemical catalysis, and genome integrity surveillance. READ MORE

  4. 7. Host-Virus Interactions in Asthma and COPD

    Author : Cristopher McCrae; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Asthma; COPD; Exacerbation; Virus; Interferon;

    Abstract : Asthma and chronic obstructive pulmonary disease (COPD) are associated with periods of worsened symptoms, known as exacerbations. Severe exac-erbations can result in hospitalisation, irreversible decline of the disease and sometimes death. Thus, exacerbations are a major cause of morbidity, mortality and healthcare cost. READ MORE

  5. 8. Arthritogenecity of RNA and its degradation products

    Author : Fariba Zare; Göteborgs universitet; []
    Keywords : dsRNA; ssRNA; virus; arthritis; TLR3; IL-1R; IFNalpha beta receptor; plasminogen; tissue factor; uric acid; inflammation; arthritis; neutrophils;

    Abstract : Viral infections often lead to arthralgias and overt arthritic states. Expression of double stranded RNA (dsRNA) is a common feature of all viruses during their replication and it has been suggested that it is able to induce production of pro-inflammatory cytokines, e.g., interferon-alpha (IFN-alpha). READ MORE

  6. 9. Detection and Quantification of Variable Viral RNA by Real-Time PCR Assays

    Author : Shaman Muradrasoli; Jonas Blomberg; Göran Friman; Maria Brytting; Uppsala universitet; []
    Keywords : Virology; Diagnosis of Viral RNA; QPCR; RNA virus; broadly targeted PCR; probe design strategy; Infectious diseases; Medicin; Medicine;

    Abstract : As the area of nucleic acid based technologies develops, so will our understanding of how structural variations in DNA and RNA pathogens are associated with disease. The overall goal of this thesis is the development of broadly targeted measurement techniques for variable viral RNA by Real-Time PCR (here referred to as quantitative reverse transcriptase PCR, QRT-PCR). READ MORE

  7. 10. Structural Decorations in Viruses : Unraveling Acquired Functional Structures in Icosahedral RNA Virus Capsids

    Author : Han Wang; Kenta Okamoto; Sarah Butcher; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Viruses; RNA viruses; capsid; structure; cryo-EM; Molekylär biovetenskap; Molecular Life Sciences;

    Abstract : Viruses have a profound impact worldwide, posing challenges to animal welfare, agriculture, human health, and the ecosystem. This thesis examines the realm of non-enveloped icosahedral double-stranded (ds)RNA and single-stranded (ss)RNA viruses through three studies. READ MORE