Search for dissertations about: "RNA-Seq"

Showing result 1 - 5 of 117 swedish dissertations containing the word RNA-Seq.

2. 1. Utilization of single-cell RNA-Seq and genome-scale modeling for investigating cancer metabolism

   Author : Johan Gustafsson; Chalmers tekniska högskola; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; genome-scale metabolic modeling; cancer; metabolism; single-cell RNA-Seq;

   Abstract : Cancer remains a leading cause of death worldwide, and its dysregulated metabolism is a promising target for therapy. However, metabolism is complex to study – the metabolism of a cell involves the interplay of thousands of chemical reactions that are combined in different ways across tissues and cell types. READ MORE

4. 2. Integration of RNA and protein expression profiles to study human cells

   Author : Frida Danielsson; Emma Lundberg; Mikael Huss; Mathias Uhlén; Christine Vogel; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; RNA-seq; Transcriptomics; Proteomics; Malignant transformation; Cancer; Functional enrichment; Bioteknologi; Biotechnology; Medical Technology; Medicinsk teknologi;

   Abstract : Cellular life is highly complex. In order to expand our understanding of the workings of human cells, in particular in the context of health and disease, detailed knowledge about the underlying molecular systems is needed. READ MORE

5. 3. Persistent infection by Yersinia pseudotuberculosis

   Author : Kemal Avican; Maria Fällman; Wyndham W. Lathem; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Persistent infection; RNA-seq; PMNs; Yersinia; Transcriptome; wrba; fnr; rovA; arcA; rfaH; molekylärbiologi; Molecular Biology; Infectious Diseases; infektionssjukdomar; immunologi; Immunology;

   Abstract : Enteropathogenic Yersinia species can infect many mammalian organs such as the small intestine, cecum, Peyer’s patches, liver, spleen, and lung and cause diseases that resemble a typhoid-like syndrome, as seen for other enteropathogens. We found that sublethal infection doses of Y. READ MORE

6. 4. Computational methods for analysis and visualization of spatially resolved transcriptomes

   Author : Jose Fernandez Navarro; Joakim Lundeberg; Martin Hemberg; KTH; []
   Keywords : RNA; RNA-seq; single cell; scRNA-seq; transcriptomics; spatial transcriptomics; brain; 3D; Alzheimer’s disease; Bioteknologi; Biotechnology;

   Abstract : Characterizing the expression level of genes (transcriptome) in cells and tis- sues is essential for understanding the biological processes of multicellular or- ganisms. RNA sequencing (RNA-seq) has gained traction in the last decade as a powerful tool that provides an accurate quantitative representation of the transcriptome in tissues. READ MORE

7. 5. Sex, Molecules, and Gene control : Ecophysiological and evolutionary aspects of key sponge species from Antarctic shallow waters and the deep sea

   Author : Vasiliki Koutsouveli; Paco Cárdenas; Anders Backlund; Ana Riesgo; Cassandra G. Extavour; Uppsala universitet; []
   Keywords : Porifera; Demospongiae; Geodia spp.; Phakellia ventilabrum; reproduction; gametogenesis; Antarctica; deep sea; sponge grounds; histology; molecular machinery; electron microscopy; RNA-seq; proteomics; lipidomics; Farmakognosi; Pharmacognosy;

   Abstract : Very little is known about the ecophysiological aspects of Porifera (sponges) from Antarctica and North Atlantic, even though they are keystone components of these habitats. Being the earliest diverging metazoan lineage, sponges also play a fundamental role in our understanding of animal evolution. READ MORE