Search for dissertations about: "RNA-seq"

Showing result 11 - 15 of 117 swedish dissertations containing the word RNA-seq.

  2. 11. Genome-wide epigenetic profiling of B cell leukemia and lymphoma

    Author : Mohammad Hamdy Abdelrazak Morsy; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CLL; PRC2; EZH2; Epigenetics; CpG islands; DNA methylation; ChIP-seq; RNA-seq;

    Abstract : Epigenetic modifications, at the level of DNA methylation and post-translational modifications of histone tails cooperatively function in the organization of the genome, and thereby establish the gene expression profiles, phenotypes, and cellular fates. In this work, we investigated the aberrant epigenome in chronic lymphocytic leukemia (CLL) which is one of the most frequent lymphoid malignancies in the west including the Nordic countries. READ MORE

  4. 12. Computational methods for analysis of spatial transcriptomics data : An exploration of the spatial gene expression landscape

    Author : Alma Andersson; Joakim Lundeberg; Omer Bayraktar; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; spatial transcriptomics; machine learning; data analysis; RNA-seq; probabilistic; statistical; models; Biotechnology; Bioteknologi;

    Abstract : Transcriptomics techniques, whether in the form of bulk, single cell/nuclei, or spatial methods have fueled a substantial expansion of our knowledge about the biological systems within and around us. In addition, the rate of innovation has accelerated over the last decade, resulting in a multitude of technological advances and new methods for generation of transcriptomics data. READ MORE

  5. 13. Genomic and transcriptomic investigation of reproductive incompatibility in Drosophila

    Author : Guilherme Costa Baião; Lisa Klasson; Alistair Darby; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Wolbachia; Drosophila; Drosophila paulistorum; Differential Gene Expression; Reproductive Incompatibility; Reproductive Isolation; Comparative Genomics; Transcriptomics; RNA-Seq; Heteroplasmy; Mitochondria; Genomic conflict; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution;

    Abstract : Both nuclear and cytoplasmic elements can contribute to the emergence of reproductive incompatibilities that influence evolution and speciation. In the projects that compose this thesis, we use genomics and transcriptomics to study some of those elements in Drosophila. READ MORE

  6. 14. How can an organism´s life experience affect their descendants? Insights from epigenetic and transgenerational effects of chemical exposure in zebrafish

    Author : Mélanie Blanc; Steffen Keiter; Joëlle Rüegg; Xavier Cousin; Nikolai Scherbak; Michael K. Skinner; Örebro universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Neurotoxicity; behavior; RNA-Seq; RRBS; TEI; permethrin; PCBs; PBDEs; coumarin 47;

    Abstract : Environmental pollution causes approx. 10% of human diseases, and some develop in the progeny because of parental exposure. Effects passed on to subsequent generations may be a consequence of genetic mutations, or of inherited changes in epigenetic patterns. READ MORE

  7. 15. Ecology and evolution of coastal Baltic Sea 'dead zone' sediments

    Author : Elias Broman; Mark Dopson; Nils Risgaard-Petersen; Linnéuniversitetet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Baltic Sea; sediment; oxygen; metatranscriptomics; metagenomics; 16S rRNA gene; RNA-seq; dead zone; re-oxygenation; Akvatisk ekologi; Aquatic Ecology;

    Abstract : Since industrialization and the release of agricultural fertilizers began, coastal and open waters of the Baltic Sea have been loaded with nutrients. This has increased the growth of algal blooms and because a portion of the algal organic matter sinks to the sea floor, hypoxia has increased. READ MORE