Search for dissertations about: "RNA-seq"
Showing result 16 - 20 of 117 swedish dissertations containing the word RNA-seq.
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16. Exploring genetic heterogeneity in cancer using high-throughput DNA and RNA sequencing
Abstract : High-throughput sequencing (HTS) technology has revolutionised the biomedical sciences, where it is used to analyse the genetic makeup and gene expression patterns of both primary patient tissue samples and models cultivated in vitro. This makes it especially useful for research on cancer, a disease that is characterised by its deadliness and genetic heterogeneity. READ MORE
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17. Chromosome-specific adaptations of RNA stability and the roles of the roX RNAs in dosage compensation
Abstract : Sex chromosomes evolved from an ancient pair of autosomes and the Y chromosome lost most of its genetic information in the process. This created two kinds of genomic imbalances: the first one between males (XY) and females (XX) and the second one between the sex chromosomes and the autosomes (X:AA). READ MORE
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18. Massively Parallel Sequencing of Gene Fusion-Associated Sarcomas
Abstract : .... READ MORE
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19. Functional Studies of Genes Associated with Muscle Growth in Pigs and Hair Greying in Horses
Abstract : Domestic animals have become very different from their wild ancestors during domestication and animal breeding. This provides a good model to unravel the molecular mechanisms underlying phenotypic variation. In my thesis I have studied genes affecting two important traits, leanness in pigs and hair greying-associated melanoma in horses. READ MORE
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20. Mapping and annotating the mammalian body-wide protein-coding gene expression
Abstract : A central aim of fundamental research is to create conditions necessary for fueling further research and innovation. Our understanding of basic biology is central for future developments of tools for diagnosing, monitoring, and treating disease. READ MORE