Search for dissertations about: "RNAi screen"

Showing result 1 - 5 of 15 swedish dissertations containing the words RNAi screen.

  1. 1. Connecting Systemic RNAi to the Endomembrane System in Caenorhabditis elegans

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Benjamin T. Holmgren; Uppsala universitet.; [2017]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Systemic RNAi; RNAi inheritance; Endomembrane system; Late endosome; SID-5; SEC-22; SYX-6; C12D8.1; RNA; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Abstract : RNA interference (RNAi) is a gene regulation mechanism conserved among eukaryotes. To silence gene expression, RNAi relies on a short single-stranded guide RNA to steer the RNA-induced Silencing Complex (RISC) to mRNAs with guide strand-complementary sequences. RNAi is a highly membrane-associated process. READ MORE

  2. 2. Systemic RNAi Relies on the Endomembrane System in Caenorhabditis elegans

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Yani Zhao; Uppsala universitet.; [2017]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Systemic RNAi; RNAi inheritance; late endosomes MVBs; SID-5; SEC-22; SYX-6; C12D8.1; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Abstract : The membrane system of a eukaryotic cell is a large and complex system handling the transport, exchange and degradation of many kinds of material. Recent research shows that double-stranded RNA (dsRNA) mediated gene silencing (RNA interference) is a membrane related process. READ MORE

  3. 3. The p97 ATPase and the Drosophila Proteasome Protein Unfolding and Regulation

    University dissertation from Stockholm : Department of Molecular Biology and Functional Genomics, Stockholm University

    Author : Kristian Björk Grimberg; Stockholms universitet.; [2010]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; proteasome; ubiquitin; p97; unfolding; regulation; RNAi screen; high-throughput screen; cnc; basic leucine zipper; transcription factors; proteasome inhibition; NATURAL SCIENCES Biology Cell and molecular biology Molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi Molekylärbiologi; Molecular Biology; molekylärbiologi;

    Abstract : For all living systems, there is a requirement to recycle and regulate proteins. In eukaryotic organisms this is accomplished by the proteasome. The p97 ATPase is another highly conserved and essential complex present throughout the eukaryotic cell. READ MORE

  4. 4. Identification of intrinsic regulators in normal and malignant human hematopoiesis. An RNA-interference approach

    University dissertation from Lund University, Faculty of Medicine

    Author : Roman Galeev; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2018]
    Keywords : hematopoietic stem cell; RNA interference; Acute myeloid leukemia; myelodysplastic syndrome; genetic screens; next generation sequencing; genetic regulators;

    Abstract : Bildandet av blodceller, hematopoesen, utgår från ett litet antal av de så kallade hematopoetiska stamceller som sitter i vår benmärg. Dessa celler har förmågan att ge upphov till alla mogna blodcellstyper av de tre hematopoetiska linjerna, samtidigt som de genom celldelning bibehåller sin egna mängd. READ MORE

  5. 5. Signaling pathways in Drosophila immunity

    University dissertation from Stockholm : Department of Molecular Biology and Functional Genomics, Stockholm University

    Author : Shiva Seyedoleslami Esfahani; Stockholms universitet.; [2011]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Drosophila immunity; signaling pathways; Cactus; NFκB; Molecular Biology; molekylärbiologi;

    Abstract : Drosophila relies on innate immunity to protect itself from its hostile environment throughout its life cycle. Despite the remarkable progress in understanding many aspects of Drosophila immunity, there are still big gaps in our knowledge. READ MORE