Search for dissertations about: "RNAi screen"
Showing result 6 - 10 of 15 swedish dissertations containing the words RNAi screen.
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6. The Path to Destruction : Understanding the mechanism and regulation of proteasomal degradation
Abstract : A majority of intracellular proteins are degraded by the ubiquitin proteasome system (UPS). In this thesis, both the mechanism of the degradation and the regulation of UPS have been investigated. The importance of the p97 ATPase for proteasomal degradation of cytosolic substrates was examined. READ MORE
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7. New modifiers of insulin signalling identified by interaction screens with ASNA-1 in C. elegans
Abstract : Background: Insulin is a hormone released by the pancreatic beta cells in response to elevated levels of nutrients in the blood. Insulin triggers the uptake of glucose, fatty acids and amino acids into the liver, adipose tissue and muscles. READ MORE
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8. F‐box proteins as regulators of oncogenic pathways by ubiquitylation
Abstract : F-box proteins are the substrate-recognition components of the SCF E3 ubiquitin ligases that catalyze the ubiquitylation of many key cell cycle regulators. Functional studies indicate that the ubiquitin-proteasome system participates in the control of nearly all cellular processes through the timely degradation of short-lived regulatory proteins. READ MORE
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9. Functional studies of deubiquitinating enzymes
Abstract : The attachment of ubiquitin to substrate proteins is a key process in regulating cellular events such as cell cycle progression, signal transduction, differentiation, apoptosis, and the clearance of misfolded or aberrant proteins. Like other post-translational modifications, ubiquitination is also reversible. READ MORE
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10. Toll-mediated cellular immune response in Drosophila melanogaster
Abstract : Insects are amongst the most abundant and diversified multi-cellular organisms on earth. As pollinators of the vast majority of our food crops their socio-economic value is hard to overestimate. READ MORE
