Search for dissertations about: "RNAse P"
Showing result 1 - 5 of 19 swedish dissertations containing the words RNAse P.
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1. Conformationally Constrained Nucleosides : Design, Synthesis, and Biochemical Evaluation of Modified Antisense Oligonucleotides
Abstract : This thesis is concerned with synthesis, structure and biochemical analysis of chemically modified oligonucleotides with potential therapeutic applications. The three types of chemical modifications described here are: (a) A North-East locked 1',2'-azetidine nucleoside (b) A North locked 2',4'-cyanomethylene bridged nucleoside and (c) A 2',4'-aza-ENA-T nucleoside. READ MORE
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2. Investigation of RNase P active site residues and catalytic domain interaction
Abstract : RNase P is an essential endoribonuclease responsible for the maturation of the tRNA 5’end. The RNase P family encompasses the ribozyme based, RNase P RNP, and proteinaceous RNase P (PRORP). The ribozyme based RNase P is widely distributed in most species while PRORP has so far mainly been found in some eukaryotic cells. READ MORE
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3. Metal ion cooperativity in Escherichia coli RNase P RNA
Abstract : RNase P is an essential ribonuclease responsible for removal of the 5’ leader of tRNA precursors. Bacterial RNase P consists of an RNA subunit and a small basic protein. The catalytic activity is associated with the RNA subunit, i.e. READ MORE
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4. Distal to Proximal—Functional Coupling in RNase P RNA-mediated Catalysis
Abstract : RNase P is a ubiquitous ribonuclease responsible for removing the 5’ leader of tRNA precursor. Bacterial RNase P contains one RNA (RPR) and one protein (RPP) subunit. However, the number of protein variants depends on the origin. The RNA subunit is the catalytic subunit that in vitro cleaves its substrate with and without the protein subunit. READ MORE
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5. Computational identification of non-coding RNAs
Abstract : A large amount of genomic information is now becoming available. Suitable bioinformatic tools to organize and analyze this vast amount of information are therefore important. In the case of protein genes, the majority of these may be correctly identified using standard search methods that are based on sequence alignment. READ MORE