Search for dissertations about: "RTK"

Showing result 1 - 5 of 40 swedish dissertations containing the word RTK.

  1. 1. Receptor tyrosine kinase c-Kit signalling in hematopoietic progenitor cells

    University dissertation from Umeå : Medicinsk biovetenskap

    Author : Charlotte Edling; Bengt Hallberg; Pontus Aspenström; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; RTK; c-Kit; MAPK; PI3K; PKC; hematopoietic cells; proliferation; differentiation; apoptosis; MEDICINE Morphology; cell biology; pathology Pathology; MEDICIN Morfologi; cellbiologi; patologi Patologi;

    Abstract : The receptor tyrosine kinase (RTK) c-Kit is expressed in hematopoietic stem and progenitor cells, mast cells and in several non-hematopoietic tissues. In the hematopoietic system c-Kit and its ligand Steel Factor (SF, aka Stem Cell Factor) are critical for proliferation, survival and differentiation. READ MORE

  2. 2. Deciphering the Alk signaling pathway in Drosophila

    University dissertation from Umeå : Umeå Universitet

    Author : Fredrik Hugosson; Ruth H. Palmer; Osamu Shimmi; [2015]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Drosophila; Alk; RTK; visceral mesoderm; signal transduction; growth factor; transcription factor; molekylärbiologi; Molecular Biology;

    Abstract : In Drosophilamelanogaster the visceral mesoderm (VM) develops during embryogenesis in a process where myoblasts become specified to generate two distinct cell types, the founder cells (FCs) and the fusion competent myoblasts (FCMs) that consequently fuses. The cell specification is dependent on cell signaling mediated by the receptor tyrosine kinase (RTK) Anaplastic lymphoma kinase (Alk) and its ligand Jelly belly (Jeb), how this further sets up different identity programs that drive myoblasts to differentiate into FCs and FCMs is still not well understood. READ MORE

  3. 3. Anaplastic Lymphoma Kinase mutations and downstream signalling

    University dissertation from Umeå : Umeå Universitet

    Author : Christina Schönherr; Ruth H Palmer; Aristidis Moustakas; [2012]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Anaplastic Lymphoma Kinase; oncogene; RTK; neuroblastoma; crizotinib; NVP-TAE684; gain-of-function; MYCN; transcription factor; small GTPase; Rap1; C3G; PC12 cells; neurite outgrowth; molecular cell biology; molekylär cellbiologi;

    Abstract : The oncogene Anaplastic Lymphoma Kinase (ALK) is a Receptor Tyrosine Kinase (RTK) and was initially discovered as the fusion protein NPM (nucleophosmin)-ALK in a subset of Anaplastic Large Cell Lymphomas (ALCL). Since then more fusion proteins have been identified in a variety of cancers. READ MORE

  4. 4. Harnessing the power of model systems to investigate regulation of Anaplastic Lymphoma Kinase function

    University dissertation from Umea : Academic Publications

    Author : Patricia Mendoza-Garcia; Ruth Palmer; Jan Larsson; Åsa Rasmuson Lestander; Stefan Luschnig; [2019]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; RTK; ALK; Drosophila; Danio rerio; ALKALs; signal transduction; transcription factor; visceral mesoderm; iridophores; neural crest; molekylärbiologi; Molecular Biology;

    Abstract : The anaplastic lymphoma kinase (ALK), initially identified as a translocation partner in anaplastic large cell lymphoma (ALCL), has been described in a number of tumors such as neuroblastoma. Neuroblastoma is a neural crest derived malignancy of the sympathetic nervous system. READ MORE

  5. 5. Signaling determinants in Trojan horse-mediated dissemination of Toxoplasma gondii

    University dissertation from Stockholm : Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University

    Author : Einar B. Ólafsson; Antonio Barragan; Eva Frickel; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Apicomplexa; leukocyte motility; dendritic cell; amoeboid migration; host-parasite interactions; podosome; integrin; ITGB1; ECM; MAT; TIMP; MMP; MAPK; Erk; RTK; HGFR; Ras; calcium; VDCC; VGCC; calmodulin; CaMkII; CD63; FAK; SRC; Pi3k; hypermigration; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Toxoplasma gondii is an obligate intracellular parasite that infects all warm-blooded vertebrates including one third of the global human population. While infection is typically asymptomatic in healthy human hosts, reactivated and acute infection in immunosuppressed or immunecompromised individuals can lead to lethal toxoplasmic encephalitis After ingestion, the parasite crosses the intestinal epithelium and rapidly achieves systemic dissemination, ultimately establishing chronic infection in the brain. READ MORE