Search for dissertations about: "RTK"

Showing result 6 - 10 of 45 swedish dissertations containing the word RTK.

  2. 6. Studies on signaling pathways induced by FLT3, an important oncogene in AML

    Author : Elena Razumovskaya; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FLT3; AML; RTK; oncogene; ERK5; hematopoiesis;

    Abstract : FLT3, a receptor tyrosine kinase, is expressed in hematopoietic progenitor cells. FLT3-ITD (internal tandem duplication) and D835 mutations are found in approximately 30% and 7% of Acute Myeloid Leukemia (AML) patients respectively, and correlate with a poor prognosis, thus making the mutated receptor a potential therapeutic target. READ MORE

  4. 7. Cbl in Regulation of Growth Factor Receptor Endocytosis and Actin Dynamics

    Author : Iwona Szymkiewicz; Ivan Dikic; Silvia Giordano; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; RTK; Cbl; endocytosis; ubiquitination; actin; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; Molekylär cellbiologi; Molecular Cellbiology;

    Abstract : Proteins belonging to the Cbl family are multidomain scaffolds that participate in numerous processes, assembling signaling complexes and mediating attachment of ubiquitin to receptor and non-receptor tyrosine kinases.We characterized a novel role for Cbl and Cbl-b in ligand-dependent internalization of growth factor receptors. READ MORE

  5. 8. Axl RTK and microRNAs in urogenital cancers

    Author : Helena Fritz; Malmö Klinisk kemi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : This thesis is based on four projects focused on the Axl receptor tyrosine kinase (RTK) and microRNAs in clear cell renal cell carcinoma (ccRCC) and in prostate cancer (PCa). Paper I focuses on differentially expressed microRNAs in ccRCC. READ MORE

  6. 9. Apoptosis Regulation in Multiple Myeloma

    Author : Lina Dimberg; Helena Jernberg Wiklund; Kenneth Nilsson; Marie Arsenian Henriksson; Uppsala universitet; []
    Keywords : Biomedicine; multiple myeloma; apoptosis; survival; IFN; Stat1; Stat3; IGF-I; RTK inhibitor; PPP; IAP; Fas CD95; dexamethasone; Biomedicin;

    Abstract : Multiple myeloma (MM) is a virtually incurable B cell malignancy of the bone marrow. One important part of tumor progression and an obstacle for successful therapy is resistance to apoptosis. To combat this resistance, the mechanisms of apoptosis and survival in MM must be better defined. READ MORE

  7. 10. The Regulation of Growth and Survival in Human Multiple Myeloma Cells by IGF-I Receptor Signaling

    Author : Thomas Strömberg; Helena Jernberg Wiklund; Kenneth Nilsson; Anders Waage; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; Multiple myeloma; IGF-IR; apoptosis; somatostatin; octreotide; dexamethasone; GSK-3; mTOR; rapamycin; RTK inhibitor; Patologi; Pathology; Patologi;

    Abstract : Multiple myeloma (MM) is an incurable B-cell malignancy mainly localized to the bone marrow. Our aim was to examine the growth- and survival-promoting role of the IGF-IR and its downstream signaling components in MM cells to identify potential targets for therapy. READ MORE