Search for dissertations about: "Rac1"

Showing result 21 - 25 of 48 swedish dissertations containing the word Rac1.

  2. 21. Mechanisms of neutrophil recruitment in septic lung injury

    Author : Karzan Palani; Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sepsis; infection; neutrophil; lung; chemokines; apoptosis; CD44; F-actin; peptides;

    Abstract : Sepsis is one of leading cause of death despite aggressive surgical intervention and antibiotic therapies. Excessive neutrophil recruitment is a major feature in early phase with immune system dysfunction at later phase. Lung is the most vulnerable, critical and sensitive organ during sepsis process. READ MORE

  4. 22. Wnts in development : focus on midbrain

    Author : Emma Rakel Andersson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Studies in the field of embryonic development reveal the temporal and spatial requirement of specific genes/proteins in the formation of a given tissue. The specific knowledge of which genes/proteins regulate development of the ventral midbrain (VM) provides a guideline for the in vitro differentiation of specific cell types therein, such as dopaminergic (DA) neurons. READ MORE

  5. 23. The atypical Rho GTPase RhoD and its role in cellular dynamics

    Author : Magdalena Blom; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Despite its discovery 20 years ago, the accumulated knowledge about the Rho member RhoD is scarce. Instead, the vast majority of studies concerning Rho GTPases has focused on the three classical members RhoA, Cdc42 and Rac1. In contrast, RhoD is considered an atypical Rho GTPase, with an aberrant GTP/GDP cycling and an unknown regulation. READ MORE

  6. 24. Cell signaling by Rho and Miro GTPases : Studies of Rho GTPases in Cytoskeletal Reorganizations and of Miro GTPases in Mitochondrial Dynamics

    Author : Åsa Fransson; Pontus Aspenström; Harry Mellor; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Ras superfamily; Rho GTPases; cytoskeleton; Miro GTPases; mitochondrial dynamics; Cell and molecular biology; Cell- och molekylärbiologi;

    Abstract : The Ras superfamily of GTPases embraces six major branches of proteins: the Ras, Rab, Ran, Arf, Rho and Miro subfamilies. The majority of GTPases function as binary switches that cycle between active GTP-bound and inactive GDP-bound states. This thesis will focus primarily on the biological functions of the Rho and Miro proteins. READ MORE

  7. 25. Cell-matrix interactions : master regulators of cancer cell fate?

    Author : Sara Göransson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The development and homeostasis of a multicellular organism require fundamental biological processes like cell proliferation, cell differentiation, cell migration, and controlled cell death. The extracellular matrix (ECM) guides many of these functions, via cell-matrix interactions that function as mechanical and biochemical signaling hubs. READ MORE