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Showing result 1 - 5 of 398 swedish dissertations matching the above criteria.

2. 1. Cellular effects of ionizing radiation : Relevant for understanding cancer risk after medical and environmental radiation exposures

   Author : Pamela Chiaka Akuwudike; Andrzej Wojcik; Lovisa Lundholm; Kerstin Borgmann; Stockholms universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiation; DNA damage; radiation-induced carcinogenesis; second primary cancer; cisplatin chemoradiotherapy; dose fractionation; low dose; low dose rate; dose and dose rate effectiveness factor DDREF ; molekylär biovetenskap; Molecular Bioscience;

   Abstract : Radiation-induced cancers are stochastic and delayed effects of exposure to ionizing radiation. The dose-response relationship for radiation-induced cancers at both low dose/low dose rates and high doses (doses encountered during radiotherapy) remains unclear. READ MORE

4. 2. Dose painting : Can radiotherapy be improved with image driven dose-responses derived from retrospective radiotherapy data?

   Author : Eric Grönlund; Anders Ahnesjö; Silvia Johansson; Daniela Thorwarth; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiotherapy; functional imaging; dose painting; dose painting by numbers; robust optimization; Medicinsk radiofysik; Medical Radiophysics;

   Abstract : The main aim of curative radiotherapy for cancer is to prescribe and deliver doses that eradicate the tumor and spare the normal healthy tissues. Radiotherapy is commonly performed by delivering a homogeneous radiation dose to the tumor. READ MORE

5. 3. Biomarkers of ionising radiation relevant to carcinogenesis : Dose, dose rate and LET dependency of the responses

   Author : Milagrosa López Riego; Andrzej Wojcik; Lovisa Lundholm; Alexandros G. Georgakilas; Stockholms universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ionising radiation; low dose; low dose rate; linear energy transfer LET ; mixed beams; dose and dose rate effectiveness factor DDREF ; cancer; DNA damage response; biomarkers; molekylär biovetenskap; Molecular Bioscience;

   Abstract : A better understanding of the relationship between ionising radiation (IR) dose, dose rate and radiation quality, and the risk of stochastic effects would improve risk extrapolation from atomic bomb survivors’ data. Owing to insufficient statistical power of epidemiological studies to detect excess incidence of cancer following low doses of IR delivered at low dose rates (LDLDR), as typically encountered in most common human exposure scenarios, radiobiological experiments are fundamental to describe the biological effectiveness of LDLDR and to define the underlying molecular mechanisms. READ MORE

6. 4. Energy and intensity modulated radiation therapy with electrons

   Author : Lennart Olofsson; Mikael Karlsson; Magnus Karlsson; Björn Zackrisson; Erik Traneus; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiation sciences; Radiation therapy; Conformal therapy; IMRT; Electrons; Electron treatment head; Electron MLC; Bremsstrahlung reduction; Integral dose; Penumbra; Output factor; Strålningsvetenskap; Radiation biology; Strålningsbiologi; radiofysik; radiation physics;

   Abstract : In recent years intensity modulated radiation therapy with photons (xIMRT) has gained attention due to its ability to reduce the dose in the tissues close to the tumour volume. However, this technique also results in a large low dose volume. READ MORE

7. 5. The microdosimetric variance-covariance method used for beam quality characterization in radiation protection and radiation therapy

   Author : Jan Erik Lillhök; Lennart Lindborg; Bernd Grosswendt; Stockholms universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ionizing radiation; radiation quality; radiation protection; radiation therapy; microdosimetry; nanodosimetry; variance-covariance method; Radiological physics; Radiofysik; medicinsk strålningsfysik; Medical Radiation Physics;

   Abstract : Radiation quality is described by the RBE (relative biological effectiveness) that varies with the ionizing ability of the radiation. Microdosimetric quantities describe distributions of energy imparted to small volumes and can be related to RBE. READ MORE