Search for dissertations about: "Radical cyclizations"

Found 4 swedish dissertations containing the words Radical cyclizations.

  2. 1. Radical Cyclization Approaches to Pyrrolidines

    Author : Magnus Beşev; Troels Skrydstrup; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Radical cyclization; diastereselectivity; pyrrolidine; pyrroline; thiazoline; aziridine; Organisk kemi; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

    Abstract : Five-membered rings are readily prepared by 5-exo-trig radical cyclization. This thesis is concerned with novel methodology for pyrrolidine synthesis. We have synthesised selenium containing radical precursors from aziridines and α-phenylseleno ketones, and cyclized them to 2,4- and 3,4-disubstituted pyrrolidines. READ MORE

  4. 2. Carbon-Carbon Bond Formation via Radical Cyclization and Transition Metal Catalysis

    Author : Puneet Srivastava; Lars Engman; Ullrich Jahn; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Radical cyclizations; transition metal catalysis; Chemistry; Kemi; Chemistry with specialization in Organic Chemistry; Kemi med inriktning mot organisk kemi;

    Abstract : Free radical cyclization methodology has been used extensively in synthesis for manipulation of complex molecules such as alkaloids, terpenes, carbohydrates, peptides and nucleic acids. The methodology has emerged as a result of work by physical organic chemists who determined rate constants for the most common radical reactions used in organic synthesis. READ MORE

  5. 3. Development of Lewis acid mediated stereoselective synthesis of nitrogen containing heterocycles

    Author : Åsa Sjöholm Timén; KTH; []
    Keywords : organic chemistry;

    Abstract : This thesis deals with the development of syntheticmethodologies for the preparation of enantio- anddiastereomerically enriched nitrogen-containingheterocycles.Asymmetric Lewis acid mediated Diels-Alder reactions with2H-azirines as dienophiles have been studied. READ MORE

  6. 4. Exploring Palladium-Mediated 11C/12C-Carbonylation Reactions : PET Tracer Development Targeting the Vesicular Acetylcholine Transporter

    Author : Sara Roslin; Mats Larhed; Gunnar Antoni; Jonas Eriksson; Luke Odell; Victor Pike; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Carbonylation; palladium; carbon-11; radiochemistry; positron emission tomography; vesicular acetylcholine transporter; vesamicol; alkyl halide; oxidative carbonylation; acylamidine; oxadiazole; heterocycle; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : The work presented herein describes the utilization and exploration of palladium-mediated incorporations of carbon monoxide and/or [11C]carbon monoxide into compounds and structural motifs with biological relevance.The first part of the thesis describes the design, synthesis and 11C-labeling of prospective PET tracers for the vesicular acetylcholine transporter (VAChT), a target affected in several neurodegenerative diseases. READ MORE