Search for dissertations about: "Radioimmunoassay methods"
Showing result 1 - 5 of 17 swedish dissertations containing the words Radioimmunoassay methods.
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1. Lipid peroxidation in vivo : Evaluation and application of methods for measurement
Abstract : Lipid peroxidation is thought to be an important factor in the pathophysiology of a number of diseases and in the process of ageing, but its measurement in vivo has been difficult. The aim of this thesis was to evaluate methods for measurement of lipid peroxidation in vivo that are suitable for clinical investigations, and to apply these methods in animal and human studies investigating basal conditions and situations associated with increased lipid peroxidation. READ MORE
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2. Methods and detection of endogenous peptides in the CNS and GI tract
Abstract : Endogenous peptides, such as enkephalins, endorphins and orexins modulate a variety of biological processes; these peptides are found in the central nervous system and periphery, including the gastrointestinal tract. One of the methods commonly used to determine localization, concentration, expression and function of endogenous peptides is the radio immunoassay (RIA). READ MORE
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3. Aspects of chronic autoimmune thyroiditis in children and adolescents
Abstract : The aims of this thesis were to 1) compare different methods for detection of antibodies against thyroglobulin (TgAb) and thyroid peroxidase (TPOAb), particulary in children with chronic autoimmune thyroditis (AIT), 2) investigate if maternal enterovirus infection is a risk factor for development of AIT in offspring, 3) ascertain the prevalence of thyroid autoantibodies in cord blood sera from children who later developed AIT, 4) develop a new reference standard for interpretation of normative thyroid volumes in Swedish children, and 5) evaluate the effect of Levothyroxine (L-thyroxine) treatment on thyroid size in children and adolescents with AIT. We found that 1) Methods based on radioimmunoassay (RIA) were more efficient in detecting both TgAb and TPOAb in children with AIT than methods based on agglutination. READ MORE
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4. Glutathione transferases : markers for renal disease
Abstract : Glutathione transferases (GST) alpha and pi were purified to homogeneity and used to develop immunochemical methods for analysis of the amount of these proteins in human urine. The methods were employed for diagnosis of renal dysfunctions caused by drugs and industrial chemicals. READ MORE
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5. Testosterone and 17beta-oestradiol secretions in children and adolescents. Assay development, levels for comparison and clinical applications
Abstract : Accurate measurements of 17beta-oestradiol and testosterone are important in clinical settings of pubertal disorders and hormone replacement therapy among children. Most assays for measurement of these steroids are optimised for fertility investigations in adults and are not sensitive enough for quantification in children. READ MORE