Search for dissertations about: "Radionuclide imaging"

Showing result 1 - 5 of 74 swedish dissertations containing the words Radionuclide imaging.

  1. 1. Development of Affibody molecules for radionuclide molecular imaging and therapy of cancer

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Hadis Honarvar; Vladimir Tolmachev; Raymond M. Reilly; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Affibody molecules; HER2; Molecular imaging; Radionuclide targeted therapy; Radionuclide molecular imaging; Labeling chemistry; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Abstract : Affibody molecules are a promising class of scaffold-based targeting proteins for radionuclide-based imaging and therapy of cancer. This thesis work is based on 5 original research articles (papers I-V), which focus on optimization of molecular design of HER2-binding Affibody variants for high contrast imaging of this predictive biomarker as well as development of Affibody molecules suitable for radionuclide-based targeted therapies. READ MORE

  2. 2. Molecular Radionuclide Imaging Using Site-specifically Labelled Recombinant Affibody Molecules Preparation and Preclinical Evaluation

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sara Ahlgren; Vladimir Tolmachev; Anna Orlova; Göran Hedenstierna; Joachim Feldwisch; Raymond Reilly; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; molecular radionuclide imaging; Affibody molecules; HER2; cancer detection; radiolabelling; technetium; indium; cobalt; SPECT; PET; MEDICINE Surgery Oncology; MEDICIN Kirurgi Onkologi; MEDICINE Physiology and pharmacology Radiological research Diagnostic radiology; MEDICIN Fysiologi och farmakologi Radiologisk forskning Diagnostisk radiologi; MEDICINE Physiology and pharmacology Radiological research Radiation biology; MEDICIN Fysiologi och farmakologi Radiologisk forskning Strålningsbiologi; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap; Medicinsk vetenskap; Medical Science;

    Abstract : Radionuclide molecular imaging is an emerging multidisciplinary technique that is used in modern medicine to visualise diseases at cellular and molecular levels. This thesis is based on five papers (I-V) and focuses on the development of site-specific radiolabelled recombinant anti-HER2 Affibody molecules and preclinical evaluations in vitro and in vivo of the labelled conjugates. READ MORE

  3. 3. Preclinical Molecular Imaging using Multi-Isotope Digital Autoradiography - Techniques and Applications

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Anders Örbom; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Autoradiography; Radioimmunotherapy; Antibodies; Molecular Imaging; Multi-Radionuclide Imaging; Silicon-strip detector;

    Abstract : Molecular imaging, both in vivo and ex vivo, is playing an increasingly important role in preclinical medical research. When using radionuclide-labeled tracers, e.g. in the development of radiopharmaceuticals for diagnostic imaging or for radionuclide therapy, quantitative in vivo imaging can be performed using emission tomography. READ MORE

  4. 4. Quantitative imaging with PET performance and applications of 76Br, 52Fe, 110mIn and 134La

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Mark Lubberink; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; PET; Positron Emission Tomography; Quantitative Imaging; bromine; iron; indium; lanthanum; Onkologi; MEDICINE Surgery Oncology; MEDICIN Kirurgi Onkologi; Oncology; onkologi;

    Abstract : The use of positron emission tomography (PET) has so far mainly been limited to a few nuclides with short half-lives such as 11C and 18F. Certain applications require nuclides with longer half-lives, such as 76Br and 52Fe. READ MORE

  5. 5. Computational patient models for simulation of dynamic gamma-camera imaging : Application to renography and peptide receptor radionuclide therapy

    University dissertation from Lund University, Faculty of Science, Department of Medical Radiation Physics

    Author : Gustav Brolin; [2017-09]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Nuclear medicine; Gamma camera; Renography; Radionuclide therapy; Internal dosimetry; Pharmacokinetics;

    Abstract : Many nuclear medicine investigations rely on gamma-camera imaging to study and quantify the distribution of radiopharmaceuticals or radionuclides in the patient as a function of time. This is typically used for diagnostic studies of physiological functions or for calculation of absorbed doses following radionuclide therapy. READ MORE